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Prolastin, a pharmaceutical preparation of purified human α1-antitrypsin, blocks endotoxin-mediated cytokine release
Backgroundα1-antitrypsin (AAT) serves primarily as an inhibitor of the elastin degrading proteases, neutrophil elastase and proteinase 3. There is ample clinical evidence that inherited severe AATExpand
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Serum and bronchial lavage fluid concentrations of IL-8, SLPI, sCD14 and sICAM-1 in patients with COPD and asthma.
BACKGROUND Airway inflammation is associated with an increased expression and release of inflammatory reactants that regulate processes of cell migration, activation and degranulation. The purpose ofExpand
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Endocrine-responsive pancreatic carcinoma: steroid binding and cytotoxicity studies in human tumor cell lines.
We have begun to investigate the steroid responsiveness of pancreatic cancer by comparing human (MiaPaCa, Colo-357, RWP-1, RWP-2) and rodent (AR42j) pancreatic tumor cell lines with cultured estrogenExpand
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Amorphic lenses: a mobility aid for patients with retinitis pigmentosa.
An amorphic lens, designed by William Feinbloom, was tested on 69 patients with retinitis pigmentosa. The results showed that one-half of the patients experienced immediate improvement in mobilityExpand
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Plasma levels of alpha1-antichymotrypsin and secretory leukocyte proteinase inhibitor in healthy and chronic obstructive pulmonary disease (COPD) subjects with and without severe α1-antitrypsin
BackgroundIndividuals with severe Z α1-antitrypsin (AAT) deficiency have a considerably increased risk of developing chronic obstructive lung disease (COPD). It has been hypothesized thatExpand
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A New Form of Experimental Diabetes
From the Departments of Medicine (Division of Clinical Pharmacology), Physiological Chemistry and Pathology of The Johns Hopkins University School of Medicine, Baltimore, Maryland. i, i-dioxide. ItExpand
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The use of noninvasive methods in the evaluation of left ventricular performance in coronary artery disease. I. Relation of systolic time intervals to angiographic assessment of coronary artery
Determination of left ventricular performance by external STI was evaluated in 113 patients with possible coronary artery disease undergoing selective coronary artery disease undergoing selectiveExpand
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Use of noninvasive methods in evaluation of left ventricular performance in coronary artery disease. II: Change in systolic time intervals after coronary artery bypass in patients with stable angina.
Serial recording of systolic time intervals (STI) was used to assess changes in left ventricular (LV) function in 92 patients with stable angina undergoing coronary angiography and LVExpand
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The effect of gossypol and 6-aminonicotinamide on tumor cell metabolism: a 31P-magnetic resonance spectroscopic study.
31P-Magnetic resonance spectroscopy has been used to assess the changes in the levels of water-soluble phosphate pools in T47-D breast carcinoma cells induced by the antimitochondrial drugs, gossypolExpand
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Secretory leukocyte protease inhibitor inhibits neutrophil apoptosis
Background and objective:  The secretory leukocyte protease inhibitor (SLPI) is a major anti‐elastase barrier at the epithelial surfaces of upper respiratory tract. In addition to its anti‐proteaseExpand
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