Author pages are created from data sourced from our academic publisher partnerships and public sources.
Normal values for hypoxic and hypercapnic ventilaroty drives in man.
To better determine the range of normal values of hypoxic and hypercapni ventilatroy drives in man, these drives were measured in 40 males and 4 females between 21 and 51 yr of age. The average… Expand
Neuromuscular relaxants as antagonists for M2 and M3 muscarinic receptors.
BACKGROUND Neuromuscular relaxants such as pancuronium bind to M2 and M3 muscarinic receptors as antagonists. Blockade of muscarinic receptors in atria of the M2 subtype mediates tachycardia. In the… Expand
Lipopolysaccharide-induced sensitization of adenylyl cyclase activity in murine macrophages.
- Y. Osawa, H. Lee, C. Hirshman, D. Xu, C. Emala
- Biology, Medicine
- American journal of physiology. Cell physiology
LPS is known to modulate macrophage responses during sepsis, including cytokine release, phagocytosis, and proliferation. Although agents that elevate cAMP reverse LPS-induced macrophage functions,… Expand
Actin reorganization in airway smooth muscle cells involves Gq and Gi-2 activation of Rho.
Extracellular stimuli induce cytoskeleton reorganization (stress-fiber formation) in cells and Ca2+ sensitization in intact smooth muscle preparations by activating signaling pathways that involve… Expand
In vivo measurements of airway reactivity using high-resolution computed tomography.
- R. Brown, C. Herold, C. Hirshman, E. Zerhouni, W. Mitzner
- The American review of respiratory disease
Changes in airway resistance are reported to account for only a portion of changes in total lung resistance. The fraction of total lung resistance caused by airway resistance is difficult to quantify… Expand
Anesthesia for Laser Surgery
Laser surgery offers several advantages to the surgeon and patient: microscopic precision, a bloodless operative field, and complete sterility. While the majority of procedures pose few problems… Expand
Inhibitory effects of thiopental, ketamine, and propofol on voltage-dependent Ca2+ channels in porcine tracheal smooth muscle cells.
BACKGROUND Intravenously administered anesthetics directly inhibit airway smooth muscle contraction. Because many anesthetic agents affect membrane ion channel function and sustained contraction of… Expand
Serotonin induces constriction and relaxation of the guinea pig airway.
- R. Baumgartner, M. Wills-Karp, M. Kaufman, M. Munakata, C. Hirshman
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 October 1990
The response of guinea pig trachea to 5-hydroxytryptamine (serotonin; 5-HT) was investigated by studying tracheal strips suspended in organ chambers for isometric tension measurements. Serotonin… Expand
Carbachol-induced actin reorganization involves Gi activation of Rho in human airway smooth muscle cells.
- H. Togashi, C. Emala, I. Hall, C. Hirshman
- Biology, Medicine
- American journal of physiology. Lung cellular and…
- 1 May 1998
To determine whether M2 muscarinic receptors are linked to the monomeric G protein Rho, we studied the effect of carbachol on actin reorganization (stress fiber formation) in cultured human airway… Expand