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The NoSAS score for screening of sleep-disordered breathing: a derivation and validation study.
- H. Marti-Soler, C. Hirotsu, +9 authors R. Heinzer
- The Lancet. Respiratory medicine
- 1 September 2016
BACKGROUND Diagnosis of sleep-disordered breathing requires overnight recordings, such as polygraphy or polysomnography. Considering the cost and low availability of these procedures, preselection of… Expand
Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis
Up to 80% of people develop a cutaneous condition closely connected to their exposure to stressful life events. Psoriasis is a chronic recurrent inflammatory skin disorder with multifactorial… Expand
Sleep complaints in the Brazilian population: Impact of socioeconomic factors
National surveys are relevant for the study of sleep epidemiology since they can provide specific data about sleep in large dimension with important implications for the health system. Thus, the aim… Expand
Interactions between sleep, stress, and metabolism: From physiological to pathological conditions
Poor sleep quality due to sleep disorders and sleep loss is highly prevalent in the modern society. Underlying mechanisms show that stress is involved in the relationship between sleep and metabolism… Expand
Sleep Fragmentation Promotes NADPH Oxidase 2-Mediated Adipose Tissue Inflammation Leading to Insulin Resistance in Mice
- S. Zhang, A. Khalyfa, +7 authors D. Gozal
- Chemistry, Medicine
- International Journal of Obesity
- 30 July 2013
Background:Short sleep has been implicated in higher risk of obesity in humans, and is associated with insulin resistance. However, the effects of fragmented sleep (SF) rather than curtailed sleep on… Expand
Chronic sleep fragmentation during the sleep period induces hypothalamic endoplasmic reticulum stress and PTP1b-mediated leptin resistance in male mice.
BACKGROUND Sleep fragmentation (SF) is highly prevalent and may constitute an important contributing factor to excessive weight gain and the metabolic syndrome. Increased endoplasmic reticulum (ER)… Expand
BRIEF REPORT: Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice
We evaluated the overall genetic damage induced by different doses of cocaine and MDMA (3,4‐Methylenedioxymethamphetamine) in several organs. One hour after intraperitoneal drug administration, mice… Expand
Impairment of male reproductive function after sleep deprivation.
- T. Alvarenga, C. Hirotsu, R. Mazaro-Costa, S. Tufik, M. Andersen
- Biology, Medicine
- Fertility and sterility
- 1 May 2015
OBJECTIVE To evaluate the influence of sleep loss on sexual behavior, hormone levels, sperm parameters, and testis-specific gene expression in male rats. DESIGN Experimental research. SETTING… Expand
Metabolic effects of intermittent hypoxia in mice: steady versus high-frequency applied hypoxia daily during the rest period.
- A. Carreras, F. Kayali, J. Zhang, C. Hirotsu, Y. Wang, D. Gozal
- Biology, Medicine
- American journal of physiology. Regulatory…
- 1 October 2012
Intermittent hypoxia (IH) is a frequent occurrence in sleep and respiratory disorders. Both human and murine studies show that IH may be implicated in metabolic dysfunction. Although the effects of… Expand
The interaction between erectile dysfunction complaints and depression in men: a cross-sectional study about sleep, hormones and quality of life
- J. H. Soterio-Pires, C. Hirotsu, L. J. Kim, L. Bittencourt, S. Tufik, M. Andersen
- International Journal of Impotence Research
- 1 March 2017
Depression (DEP) is one of the main disabling diseases and is considered a contributor factor for erectile dysfunction (ED). Both of these conditions may be associated with hormonal changes and sleep… Expand