Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells
The results demonstrate that the cannabinoid system within the CNS plays a critical role in regulating autoimmune inflammation, with the CNS directly suppressing T-cell effector function via the CB2 receptor.
Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis.
- Sachin Patel, C. T. Roelke, D. J. Rademacher, W. Cullinan, C. Hillard
- 1 December 2004
Data indicate that e CB signaling negatively modulates HPA axis function in a context-dependent manner and suggest that pharmacological augmentation of eCB signaling could serve as a novel approach to the treatment of anxiety-related disorders.
Pharmacological Evaluation of Cannabinoid Receptor Ligands in a Mouse Model of Anxiety: Further Evidence for an Anxiolytic Role for Endogenous Cannabinoid Signaling
The data indicate that activation of CB1 cannabinoid receptors reduces anxiety-like behaviors in mice and support an anxiolytic role for endogenous cannabinoid signaling and suggest that pharmacological modulation of this system could represent a new approach to the treatment of anxiety-related psychiatric disorders.
Inhibition of restraint stress‐induced neural and behavioural activation by endogenous cannabinoid signalling
- Sachin Patel, C. T. Roelke, D. J. Rademacher, C. Hillard
- Biology, PsychologyEuropean Journal of Neuroscience
- 1 February 2005
The data suggest that eCB activation of CB1 receptors opposes the behavioural and neuronal responses to aversive stimuli and hypothesize that increased CB1 receptor activity contributes to the expression of habituation to homotypic stress.
Cannabinoid CB2 Receptors and Fatty Acid Amide Hydrolase Are Selectively Overexpressed in Neuritic Plaque-Associated Glia in Alzheimer's Disease Brains
Results show that both fatty acid amide hydrolase and cannabinoid CB2 receptors are abundantly and selectively expressed in neuritic plaque-associated astrocytes and microglia, respectively, whereas the expression of CB1 receptors remains unchanged.
Suppression of Amygdalar Endocannabinoid Signaling by Stress Contributes to Activation of the Hypothalamic-Pituitary-Adrenal Axis
Findings suggest that the degree to which stressful stimuli reduce amygdalar AEA/CB1 receptor signaling contributes to the magnitude of the HPA response.
Inhibition of an equilibrative nucleoside transporter by cannabidiol: A mechanism of cannabinoid immunosuppression
- E. J. Carrier, J. Auchampach, C. Hillard
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 16 May 2006
It is demonstrated that CBD has the ability to enhance adenosine signaling through inhibition of uptake and provide a non-cannabinoid receptor mechanism by which CBD can decrease inflammation.
Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli
- K. Maresz, E. J. Carrier, E. Ponomarev, C. Hillard, B. Dittel
- BiologyJournal of Neurochemistry
- 1 October 2005
Data demonstrate that microglial cell activation is accompanied by CB2 receptor up‐regulation, suggesting that this receptor plays an important role in microglia cell function in the CNS during autoimmune‐induced inflammation.
Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret.
CB1r mediates the anti-emetic action of cannabinoids in the dorsal vagal complex and is found in the myenteric plexus of the stomach and duodenum and a novel neuroregulatory system involved in the control of emesis.
Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment
The data suggest that the endocannabinoid system in cortical and subcortical structures is differentially altered in an animal model of depression and that the effects of CUS on CB1 receptor binding site density are attenuated by antidepressant treatment while those on endOCannabinoid content are not.