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A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci
There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of α1-antitrypsin,Expand
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Variants in FAM13A are associated with chronic obstructive pulmonary disease
We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokersExpand
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The clinical features of the overlap between COPD and asthma
BackgroundThe coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects withExpand
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A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.
The genetic risk factors for chronic obstructive pulmonary disease (COPD) are still largely unknown. To date, genome-wide association studies (GWASs) of limited size have identified several novelExpand
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The clinical and genetic features of COPD-asthma overlap syndrome
Individuals with chronic obstructive pulmonary disease (COPD) and asthma are an important but poorly characterised group. The genetic determinants of COPD and asthma overlap have not been studied.Expand
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Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP.
Multiple intergenic single-nucleotide polymorphisms (SNPs) near hedgehog interacting protein (HHIP) on chromosome 4q31 have been strongly associated with pulmonary function levels andExpand
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Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations.
Case-control studies have successfully identified many significant genetic associations for complex diseases, but lack of replication has been a criticism of case-control genetic association studiesExpand
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The chronic bronchitic phenotype of COPD: an analysis of the COPDGene Study.
BACKGROUND Chronic bronchitis (CB) in patients with COPD is associated with an accelerated lung function decline and an increased risk of respiratory infections. Despite its clinical significance,Expand
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Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.
BACKGROUND The genetic risk factors for susceptibility to chronic obstructive pulmonary disease (COPD) are still largely unknown. Additional genetic variants are likely to be identified byExpand
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The COPD genetic association compendium: a comprehensive online database of COPD genetic associations.
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. COPD is thought to arise from the interaction of environmental exposures and geneticExpand
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