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Getting ready for the manned mission to Mars: the astronauts’ risk from space radiation
Space programmes are shifting towards planetary exploration and, in particular, towards missions by human beings to the Moon and to Mars. Radiation is considered to be one of the major hazards forExpand
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Carbon-Ion-Induced Activation of the NF-&kgr;B Pathway
Carbon-ion cancer therapy offers several physical and radiobiological advantages over conventional photon cancer therapy. The molecular mechanisms that determine cellular outcome, including theExpand
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X-irradiation-induced cell cycle delay and DNA double-strand breaks in the murine osteoblastic cell line OCT-1
Radiation response of bone cells, especially the bone-forming osteoblasts, is an important issue for radiotherapy in young age. A radiation-induced cell cycle arrest may enhance or accelerateExpand
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The Nuclear Factor κB pathway: A link to the immune system in the radiation response.
  • C. Hellweg
  • Chemistry, Medicine
  • Cancer letters
  • 28 November 2015
Exposure to ionizing radiation modulates immune responses in a complex dose-dependent pattern, with possible anti-inflammatory effects in the low dose range, expression of pro-inflammatory cytokinesExpand
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Galactic cosmic ray simulation at the NASA Space Radiation Laboratory.
Most accelerator-based space radiation experiments have been performed with single ion beams at fixed energies. However, the space radiation environment consists of a wide variety of ion species withExpand
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Cellular Monitoring of the Nuclear Factor κB Pathway for Assessment of Space Environmental Radiation
Abstract Baumstark-Khan, C., Hellweg, C. E., Arenz, A. and Meier, M. M. Cellular Monitoring of the Nuclear Factor κB Pathway for Assessment of Space Environmental Radiation. Radiat. Res. 164, 527–530Expand
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Tox-Box: securing drops of life - an enhanced health-related approach for risk assessment of drinking water in Germany
This article introduces ‘Tox-Box’, a joint research project designed to develop a holistic approach towards a harmonized testing strategy for exposure- and hazard-based risk management ofExpand
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Transcription Factors in the Cellular Response to Charged Particle Exposure
Charged particles, such as carbon ions, bear the promise of a more effective cancer therapy. In human spaceflight, exposure to charged particles represents an important risk factor for chronic andExpand
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Human dermal fibroblasts escape from the long-term phenocopy of senescence induced by psoralen photoactivation.
We have previously shown that following psoralen photoactivation (PUVA treatment) human dermal fibroblasts undergo long-term growth arrest as well as morphological and functional changes reminiscentExpand
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