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Androgen receptor (AR) coregulators: an overview.
AR demonstrates distinct differences in its interaction with coregulators from other steroid receptors due to differences in the functional interaction between AR domains, possibly resulting in alterations in the dynamic interactions between coregulator complexes. Expand
Androgen receptor in prostate cancer.
AR remains important in the development and progression of prostate cancer and the inhibition of AR activity through mechanisms in addition to androgen ablation, such as modulation of signal transduction pathways, may delay prostate cancer progression. Expand
The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions.
The biological activity of testosterone and dihydrotestosterone is thought to occur predominantly through binding to the androgen receptor (AR), a member of the nuclear receptor superfamily that… Expand
The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.
These findings provide a mechanistic link between androgen-regulated signaling programs and prostate cancer metastasis that operate via context-dependent interactions with extracellular constituents of the tumor microenvironment. Expand
Delayed Dark Adaptation in 11-cis-Retinol Dehydrogenase-deficient Mice
- Tom S Kim, A. Maeda, +4 authors P. Nelson
- Biology, Chemistry
- Journal of Biological Chemistry
- 11 March 2005
It is suggested that RDH11 has a measurable role in regenerating the visual pigment by complementing RDH5 as an 11-cis-RDH in RPE cells, and indicate that an additional unidentified enzyme(s) oxidizes 11- cis-retinol or that an alternative pathway contributes to the retinoid cycle. Expand
Phenotypic Analysis of Mice Lacking the Tmprss2-Encoded Protease
- Tom S Kim, C. Heinlein, R. Hackman, P. Nelson
- Medicine, Biology
- Molecular and Cellular Biology
- 1 February 2006
It is concluded that the lack of a discernible phenotype in Tmprss2 −/− mice suggests functional redundancy involving one or more of the type II transmembrane serine protease family members or other serine Proteins 2 may contribute a specialized but nonvital function that is apparent only in the context of stress, disease, or other systemic perturbation. Expand
Identification of ARA70 as a Ligand-enhanced Coactivator for the Peroxisome Proliferator-activated Receptor γ*
- C. Heinlein, H. Ting, S. Yeh, C. Chang
- Biology, Medicine
- The Journal of Biological Chemistry
- 4 June 1999
It is shown that ARA70 can function as a ligand-enhanced coactivator of PPARγ, which suggests that cross-talk may occur betweenPPARγ- and AR-mediated responses in adipocytes. Expand
Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4.
- L. Collins, Yi-Fen Lee, +7 authors Chawnshang Chang
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 19 October 2004
The generation of mice lacking TR4 by means of targeted gene disruption provides in vivo evidence that TR4 plays important roles in growth, embryonic and early postnatal pup survival, female reproductive function, and maternal behavior. Expand
Nongenomic Androgen Action
An increasing body of evidence suggests that androgens, as well as progesterone and estrogen, can exert rapid, nongenomic effects. Expand
alpha-thalassemia resulting from a negative chromosomal position effect.
During development, the CpG island associated with the alpha-globin promoter in the rearranged chromosome becomes densely methylated and insensitive to endonucleases, demonstrating the importance of the chromosomal environment in regulating globin gene expression. Expand