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Studies of hydroxyurea administered by continuous infusion. Toxicity, pharmacokinetics, and cell synchronization
Serial sampling of normal bone marrow and tumor tissue showed a modest degree of synchronization induced by continuous IV infusion of hydroxyurea, suggesting it may be useful as a synchronizing agent in humans.
Phase I evaluation of anguidine (diacetoxyscirpenol, NSC‐141537)
- W. Goodwin, C. Haas, C. Fabian, I. Heller-Bettinger, B. Hoogstraten
- Medicine, ChemistryCancer
- 1 July 1978
A toxicologic evaluation of anguidine (diacetoxyscirpenol) was completed and an infusion of 4.5 mg/M2 over 4–8 hours appears to be an acceptable compromise between CNS, cardiovascular, and GI toxicity and myelosuppression.
Phase II evaluation of bleomycin. A Southwest Oncology Group study
Bleomycin given intravenously ( i.v.) or intramuscularly (i.m.) in twice‐weekly doses of 10 mg/m2 was evaluated for efficacy and toxicity in 382 patients; all responders had shown at least improvement upon receiving 200 mg; higher total doses should be used only in responding patients.
Cisplatin and fluorouracil as neoadjuvant therapy in head and neck cancer. A preliminary report.
- R. Toohill, T. Anderson, J. Libnoch
- MedicineArchives of otolaryngology--head & neck surgery
- 1 July 1987
It was evident that the high response rates reported in previous pilot studies do not necessarily result in improved survival in these cancers, as actuarial survival was 70% in the standard treatment group as opposed to 56%" in the experimental group.
Continuous systemic 5‐fluorouracil infusion in advanced colorectal cancer: Results in 91 patients
It is concluded that continuous systemic venous infusion of 5FU produces a higher response rate than traditional bolus 5FU schedules, with apparent enhancement of survival and easily managed toxicity.
Phase I study of echinomycin.
Dose-limiting nausea, vomiting, and anorexia associated with varying degrees of renal and hepatic dysfunction proved dose-limited at the 1500-micrograms/m2 level, and thrombocytopenia was noted in 15% of patients receiving greater than or equal to 700 micrograms /m2 and was severe in 11% without an evident dose-response relationship.
Taxol-induced cell cycle arrest and apoptosis: dose-response relationship in lung cancer cells of different wild-type p53 status and under isogenic condition.
Phase I evaluation and clinical pharmacology of tricyclic nucleoside 5'-phosphate using a weekly intravenous regimen.
Prolonged retention and erratic plasma levels of the drug are probably due to extensive enterohepatic circulation, as well as repeated interconversion between TCN-P and TCN within cells.
Pancreatic cancer treated with carmustine, fluorouracil, and spironolactone: a randomized study.
Life table analysis in previously untreated patients from time of treatment shows longer survival for the three-drug group, but this difference was not statistically significant.
Phase I study of anguidine administered weekly.
- R. Belt, C. Haas, U. Joseph, W. Goodwin, D. Moore, B. Hoogstraten
- MedicineCancer treatment reports
- 1 November 1979
Anguidine was administered on a weekly schedule to 20 patients. Gastrointestinal and neurologic toxic effects were dose-limiting for both 4- and 8-hour infusions of anguidine. Myelosuppression was…