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Characterization of intracellular pH regulation in the guinea-pig ventricular myocyte.
1. Intracellular pH was recorded fluorimetrically by using carboxy-SNARF-1, AM-loaded into superfused ventricular myocytes isolated from guinea-pig heart. Intracellular acid and base loads wereExpand
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Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model
The mechanical properties of myocardium vary across the transmural aspect of the left ventricular wall. Some of these functional heterogeneities may be related to differences inExpand
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Out-of-equilibrium pH transients in the guinea-pig ventricular myocyte.
1. Following an intracellular alkali load (imposed by acetate prepulsing in CO2/HCO3- buffer), intracellular pH (pHi) of the guinea-pig ventricular myocyte (recorded from intracellular SNARFExpand
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Novel chloride-dependent acid loader in the guinea-pig ventricular myocyte: part of a dual acid-loading mechanism.
1. The fall of intracellular pH (pH1) following the reduction of extracellular pH (pH0) was investigated in guinea-pig isolated ventricular myocytes using intracellular fluorescence measurements ofExpand
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A mathematical model of pacemaker activity recorded from mouse small intestine
The pacemaker activity of interstitial cells of Cajal (ICCs) has been known to initiate the propagation of slow waves along the whole gastrointestinal tract through spontaneous and repetitiveExpand
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Implication of phosphorylation of the myosin II regulatory light chain in insulin-stimulated GLUT4 translocation in 3T3-F442A adipocytes
In adipocytes, insulin stimulates glucose transport primarily by promoting the translocation of GLUT4 to the plasma membrane. Requirements for Ca2+/ calmodulin during insulin-stimulated GLUT4Expand
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Stretch-activated currents in cardiomyocytes isolated from rabbit pulmonary veins.
Evidence is growing of a relationship between atrial dilation and atrial fibrillation (AF), the most prevalent type of arrhythmia. Pulmonary veins, which are important ectopic foci for provoking AF,Expand
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Sarcolemmal mechanisms for pHi recovery from alkalosis in the guinea-pig ventricular myocyte.
1. The mechanism of pHi recovery from an intracellular alkali load (induced by acetate prepulse or by reduction/removal of ambient PCO2) was investigated using intracellular SNARF fluorescence in theExpand
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Modelling Cl− homeostasis and volume regulation of the cardiac cell
We aim at introducing a Cl− homeostasis to the cardiac ventricular cell model (Kyoto model), which includes the sarcomere shortening and the mitochondria oxidative phosphorylation. First, we examinedExpand
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Relationship of the Cold-Heat Sensation of the Limbs and Abdomen with Physiological Biomarkers
The present study explored the relationship between the regional Cold-Heat sensation, the key indicator of the Cold-Heat patterns in traditional East Asian medicine (TEAM), and various biomarkers inExpand
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