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A Multihit Model: Colitis Lessons from the Interleukin-10–deficient Mouse
Abstract:Complex mechanisms are pulling the strings to initiate the development of inflammatory bowel disease. Current evidence indicates that an interaction of genetic susceptibilitiesExpand
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Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia
Ischemia causes an inflammatory response that is intended to restore perfusion and homeostasis yet often aggravates damage. Here we show, using conditional genetic deletion strategies together withExpand
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The Sheep Grimace Scale as an indicator of post-operative distress and pain in laboratory sheep
The EU Directive 2010/63/EU changed the requirements regarding the use of laboratory animals and raised important issues related to assessing the severity of all procedures undertaken on laboratoryExpand
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Corrigendum: Regulation of monocyte cell fate by blood vessels mediated by Notch signalling
Corrigendum: Regulation of monocyte cell fate by blood vessels mediated by Notch signalling
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Running in the wheel: Defining individual severity levels in mice
The fine-scale grading of the severity experienced by animals used in research constitutes a key element of the 3Rs (replace, reduce, and refine) principles and a legal requirement in the EuropeanExpand
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Time to Integrate to Nest Test Evaluation in a Mouse DSS-Colitis Model
Severity assessment in laboratory animals is an important issue regarding the implementation of the 3R concept into biomedical research and pivotal in current EU regulations. In mouse models ofExpand
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The chemokine receptor CX 3 CR1 coordinates monocyte recruitment and endothelial regeneration after arterial injury
Regeneration of arterial endothelium after injury is critical for the maintenance of normal blood flow, cell trafficking, and vascular function. Using mouse models of carotid injury, we show that theExpand
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Nest-building performance in rats: impact of vendor, experience, and sex
Nest building behavior has been intensely applied as a parameter for severity assessment in mice. In contrast, only a limited number of studies have reported nest building data from rats. Here, weExpand
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Semi-automated generation of pictures for the Mouse Grimace Scale: A multi-laboratory analysis (Part 2)
TLDR
The Mouse Grimace Scale (MGS) is an established method for estimating pain in mice during animal studies. Expand
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Defining body-weight reduction as a humane endpoint: a critical appraisal
In many animal experiments scientists and local authorities define a body-weight reduction of 20% or more as severe suffering and thereby as a potential parameter for humane endpoint decisions. InExpand
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