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Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest.
Inhibition of skeletal muscle S1-myosin ATPase by peroxynitrite.
- Teresa Tiago, S. Simão, M. Aureliano, F. Martin-Romero, C. Gutiérrez-Merino
- Biology, ChemistryBiochemistry
- 21 March 2006
SIN-1, at concentrations that generate micromolar peroxynitrite fluxes, impaired the ability of ADP, and it was suggested that the inhibition of F-actin-stimulated S1 Mg(2+)-ATPase activity is produced by the oxidation of highly reactive cysteines of S1, located close to the catalytic center.
Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria.
Fluorescence Measurements of Steady State Peroxynitrite Production Upon SIN-1 Decomposition: NADH Versus Dihydrodichlorofluorescein and Dihydrorhodamine 123
- F. Martin-Romero, Yolanda Gutiérrez-Martín, F. Henao, C. Gutiérrez-Merino
- BiologyJournal of Fluorescence
NADH was found to be less sensitive than dihydrorhodamine 123 and 2′,7′-dichlorodihydrofluorescein diacetate to oxidation by H2O2, which is produced during SIN-1 decomposition in common buffers.
Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis.
Vanadium and cadmium in vivo effects in teleost cardiac muscle: metal accumulation and oxidative stress markers.
Seasonal variation of exudate ofCistus ladanifer
- N. Chaves, J. Escudero, C. Gutiérrez-Merino
- Biology, MedicineJournal of Chemical Ecology
- 1 November 1993
Flavonoids are identified as the most relevant chromophores regarding the potency of the exudate as a UV-visible filter due to the similar absorption spectra of both groups of flavonoids.
Quantification and removal of glycogen phosphorylase and other enzymes associated with sarcoplasmic reticulum membrane preparations.
Hydrogen sulfide raises cytosolic calcium in neurons through activation of L-type Ca2+ channels.
- M. Garcia-Bereguiain, A. Samhan-Arias, F. Martin-Romero, C. Gutiérrez-Merino
- BiologyAntioxidants & redox signaling
It is concluded that H(2)S is a major modulator of calcium homeostasis in neurons as it induces activation of Ca(2+) entry through L-type Ca( 2+) channels, and thereby of neuronal activity.
Role of Ecological Variables in the Seasonal Variation of Flavonoid Content of Cistus ladanifer Exudate
The glasshouse and culture room experiments showed drought and high temperatures to correlate with the summer increase of the more methylated flavonoids (kaempferols and 7-methylated apigenins) in the exudate, suggesting that the secretion of more methylation flavonoid is part of the defense mechanism of the plant against the hydric stress of summer.