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ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators
We have used fluorescent 7‐nitrobenz‐2‐oxa‐1,3‐diazol‐4‐yl (NBD)‐tagged phospholipid analogues, NBD‐PE (phosphatidylethanolamine), NBD‐PC (phosphatidylcholine) and NBD‐PS (phosphatidylserine), toExpand
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A novel form of actin in Leishmania: molecular characterisation, subcellular localisation and association with subpellicular microtubules.
To study the occurrence and subcellular distribution of actin in trypanosomatid parasites, we have cloned and overexpressed Leishmania donovani actin gene in bacteria, purified the protein, andExpand
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Flagellar localization of a novel isoform of myosin, myosin XXI, in Leishmania.
Leishmania major genome analysis revealed the presence of putative genes corresponding to two myosins, which have been designated to class IB and a novel class, class XXI, specifically present inExpand
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Glycerophospholipid synthesis: improved general method and new analogs containing photoactivable groups.
Current methods for phospholipid synthesis involving acylation of sn-glycero-3-phosphorylcholine, lysolecithins, and related glycerophosphate esters are not satisfactory. WithExpand
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Chloroquine encapsulated in malaria-infected erythrocyte-specific antibody-bearing liposomes effectively controls chloroquine-resistant Plasmodium berghei infections in mice.
The suitability of liposomes as drug carriers in the treatment of drug-resistant rodent malaria was examined after covalently attaching F(ab')2 fragments of a mouse monoclonal antibody (MAb), MAbExpand
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Trafficking activity of myosin XXI is required in assembly of Leishmania flagellum
Actin-based myosin motors have a pivotal role in intracellular trafficking in eukaryotic cells. The parasitic protozoan organism Leishmania expresses a novel class of myosin, myosin XXI (Myo21),Expand
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Long-term marrow culture reveals chromosomally normal hematopoietic progenitor cells in patients with Philadelphia chromosome-positive chronic myelogenous leukemia.
We found that when marrow cells from four patients with newly diagnosed Philadelphia chromosome-positive chronic myelogenous leukemia were maintained in culture for two to four weeks, a previouslyExpand
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Tuftsin-bearing liposomes in treatment of macrophage-based infections.
The use of liposomes as drug carriers in treatment of various diseases has been explored extensively for more than 20 years. 'Conventional' liposomes, when administered in vivo by a variety ofExpand
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Actin‐depolymerizing factor, ADF/cofilin, is essentially required in assembly of Leishmania flagellum
ADF/cofilins are ubiquitous actin dynamics‐regulating proteins that have been mainly implicated in actin‐based cell motility. Trypanosomatids, e.g. Leishmania and Trypanosoma, which mediate theirExpand
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Transbilayer phosphatidylethanolamine movements in the yeast plasma membrane. Evidence for a protein-mediated, energy-dependent mechanism.
Aminophospholipid movements in the plasma membrane of higher eukaryotic cells seem to be regulated by an ATP-dependent, protein-mediated process. To examine whether similar mechanisms exist in yeastExpand
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