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Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis
Polκ and Rev1 are members of the Y family of DNA polymerases involved in tolerance to DNA damage by replicative bypass [translesion DNA synthesis (TLS)]. We demonstrate that mouse Rev1 proteinExpand
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REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo.
REV1 protein, a eukaryotic member of the Y family of DNA polymerases, is involved in the tolerance of DNA damage by translesion DNA synthesis. It is unclear how REV1 is recruited to replication fociExpand
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Ubiquitin-Binding Motifs in REV1 Protein Are Required for Its Role in the Tolerance of DNA Damage
ABSTRACT REV1 protein is a eukaryotic member of the Y family of DNA polymerases involved in the tolerance of DNA damage by replicative bypass. The precise role(s) of REV1 in this process is notExpand
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Y-family DNA polymerases in mammalian cells
Eukaryotic genomes are replicated with high fidelity to assure the faithful transmission of genetic information from one generation to the next. The accuracy of replication relies heavily on theExpand
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Conservation and novelty in the evolution of cell adhesion and extracellular matrix genes.
New proteins and modules have been invented throughout evolution. Gene "birth dates" in Caenorhabditis elegans range from the origins of cellular life through adaptation to a soil habitat. PossiblyExpand
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A Potential Role of Nuclear Matrix-associated Protein Kinase CK2 in Protection against Drug-induced Apoptosis in Cancer Cells*
Protein kinase CK2 (CK2) has long been implicated in the regulation of cell growth and proliferation. Its activity is generally elevated in rapidly proliferating tissues, and nuclear matrix (NM) isExpand
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Comparative analysis of in vivo interactions between Rev1 protein and other Y-family DNA polymerases in animals and yeasts.
Eukaryotes are endowed with multiple specialized DNA polymerases, some (if not all) of which are believed to play important roles in the tolerance of base damage during DNA replication. Among theseExpand
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Requirements for the Interaction of Mouse Polκ with Ubiquitin and Its Biological Significance*
Polκ protein is a eukaryotic member of the DinB/Polκ branch of the Y-family DNA polymerases, which are involved in the tolerance of DNA damage by replicative bypass. Despite universal conservationExpand
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SnapShot: Nucleotide Excision Repair
Nucleotide excision repair (NER) was discovered in both prokaryotes and eukaryotes in the 1960s (Friedberg et al., 2005). The process corrects a wide spectrum of damage to DNA bases that results inExpand
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DNA polymerase κ deficiency does not affect somatic hypermutation in mice
Somatic hypermutation (SH) in B cells undergoing T cell‐dependent immune responses generates high‐affinity antibodies that provide protective immunity. Most current models of SH postulate theExpand
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