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Studies on the mechanism of hydrated collagen gel reorganization by human skin fibroblasts.
During reorganization of collagen gels by human skin fibroblasts the total protein content of the gels remained approximately constant. Only 5% of the collagen was degraded, although the volume ofExpand
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Transdifferentiation of retinal pigment epithelial cells from epithelial to mesenchymal phenotype.
PURPOSE To describe and evaluate retinal pigment epithelial (RPE) cell transdifferentiation in vitro and to determine its importance to the development of proliferative vitreoretinal disorders. Expand
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The role of Müller cells in fibrocontractive retinal disorders
  • C. Guidry
  • Biology, Medicine
  • Progress in Retinal and Eye Research
  • 31 January 2005
Despite advances in surgical management of fibrocontractive retinal disorders, proliferative vitreoretinopathy (PVR) and proliferative diabetic retinopathy (PDR) remain major causes of blindness andExpand
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Binding of the proteoglycan decorin to collagen type VI.
We have examined the interactions between the small dermatan sulfate proteoglycan decorin and collagen types I-VI using solid phase binding assays. The results of these studies showed thatExpand
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Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy.
Lipids accumulate in Bruch's membrane (BrM), a specialized vascular intima of the eye, and in extracellular lesions associated with aging and age-related maculopathy (ARM). We tested the hypothesisExpand
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Contraction of hydrated collagen gels by fibroblasts: evidence for two mechanisms by which collagen fibrils are stabilized.
Studies were conducted to learn more about the mechanism by which fibroblasts contract hydrated collagen gels, a process that may be important in the supramolecular organization of the extracellularExpand
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Retina expresses microsomal triglyceride transfer protein: implications for age-related maculopathy.
The principal extracellular lesions of age-related maculopathy (ARM), the leading cause of vision loss in the elderly, involve Bruch's membrane (BrM), a thin vascular intima between the retinalExpand
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Phenotypic variation of retinal pigment epithelium in age-related macular degeneration.
PURPOSE To determine whether retinal pigment epithelium (RPE) in eyes with age-related macular degeneration (ARMD) express vimentin and alpha smooth muscle actin (alphaSMA), two cytoskeletal proteinsExpand
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Isolation and characterization of porcine Müller cells. Myofibroblastic dedifferentiation in culture.
  • C. Guidry
  • Biology, Medicine
  • Investigative ophthalmology & visual science
  • 1 April 1996
PURPOSE To characterize phenotypic and antigenic changes in isolated Müller cells during proliferation in extended culture. METHODS Müller cells were isolated from porcine retina by sequentialExpand
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Heparin modulates the organization of hydrated collagen gels and inhibits gel contraction by fibroblasts
We studied the effects of extracellular matrix components on fibroblast contraction of hydrated collagen gels. After 4-h incubations, heparin- containing collagen gels contracted only 10% comparedExpand
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