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Germination of Bacillus anthracis spores within alveolar macrophages
The fatal character of the infection caused by inhalation of Bacillus anthracis spores results from a complex pathogenic cycle involving the synthesis of toxins by the bacterium. We have shown usingExpand
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Identification and characterization of a germination operon on the virulence plasmid pXOl of Bacillus anthracis
The spores of Bacillus anthracis, the agent of anthrax disease, germinate within professional phagocytes, such as murine macrophage‐like RAW264.7 cells and alveolar macrophages. We identified aExpand
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Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha.
The lethal toxin of Bacillus anthracis consists of two proteins, PA and LF, which together induce lethal effects in animals and cause macrophage lysis. LF is a zinc-endopeptidase which cleaves twoExpand
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Identification and characterization of a germination operon on the virulence plasmid pXO1 of Bacillus anthracis.
The spores of Bacillus anthracis, the agent of anthrax disease, germinate within professional phagocytes, such as murine macrophage-like RAW264.7 cells and alveolar macrophages. We identified aExpand
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Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNγ‐induced release of NO and TNFα
The lethal toxin of Bacillus anthracis consists of two proteins, PA and LF, which together induce lethal effects in animals and cause macrophage lysis. LF is a zinc‐endopeptidase which cleaves twoExpand
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Fate of germinated Bacillus anthracis spores in primary murine macrophages
We investigated the fate of germinated Bacillus anthracis spores after their germination in Swiss murine peritoneal macrophages and in the cell line RAW264.7. We found that the lethal toxin and theExpand
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Characterization of a plasmid region involved in Bacillus anthracis toxin production and pathogenesis.
The germination of spores within the host is the initial step of anthrax infection. We have shown, using immunofluorescence staining, confocal scanning laser microscopy and image cytometry analysis,Expand
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NblA Gene Expression in Synechocystis PCC 6803 Strains Lacking DspA (Hik33) and a NblR-like Protein
Cyanobacteria respond to nutrient-limiting conditions by degrading their phycobilisomes (PBS), the light-harvesting complexes for photosynthesis. In Synechococcus sp. PCC 7942, the expression ofExpand
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Translocation of Bacillus anthracis lethal and oedema factors across endosome membranes
The two exotoxins of Bacillus anthracis, the causative agent of anthrax, are the oedema toxin (PA–EF) and the lethal toxin (PA–LF). They exert their catalytic activities within the cytosol. TheExpand
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Lethal factor of Bacillus anthracis cleaves the N-terminus of MAPKKs: analysis of the intracellular consequences in macrophages.
The lethal toxin of Bacillus anthracis consists of two proteins, PA and LF, which together induce lethal effects in some animal species and cause macrophage lysis. LF is a zinc-binding protein withExpand
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