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Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host.
APR-induced alterations initially protect the host from the harmful effects of bacteria, viruses, and parasites, however, if prolonged, these changes in the structure and function of lipoproteins will contribute to atherogenesis.
Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome.
- C. Grunfeld, M. Pang, W. Doerrler, J. Shigenaga, P. Jensen, K. Feingold
- Medicine, BiologyThe Journal of clinical endocrinology and…
- 1 May 1992
Infection causes disturbances in lipid metabolism that may be mediated by cytokines. Therefore we studied plasma lipids, lipoproteins, triglyceride (TG) metabolism, and serum cytokines in three…
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
The entire 1,370-amino-acid sequence of the human insulin receptor precursor is deduced from a single complementary DNA clone, finding sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.
Association of tenofovir exposure with kidney disease risk in HIV infection
Tenofovir exposure was independently associated with increased risk for three types of kidney disease events, and did not appear to be reversible.
Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters.
Induction of leptin during the host response to infection may contribute to the anorexia of infection, as assessed by immuknoprecipitation and Western blotting.
Management of Metabolic Complications Associated With Antiretroviral Therapy for HIV‐1 Infection: Recommendations of an International AIDS Society‐USA Panel
- M. Schambelan, C. Benson, M. Saag
- MedicineJournal of acquired immune deficiency syndromes
- 1 August 2002
These recommendations were developed to guide physicians actively involved in HIV care in the management of metabolic complications that occur primarily within the context of potent antiretroviral therapy.
Leptin regulation of the immune response and the immunodeficiency of malnutrition 1
- R. Faggioni, K. Feingold, C. Grunfeld
- BiologyFASEB journal : official publication of the…
- 1 December 2001
Low leptin levels occurring during starvation mediate the neuroendocrine and immune dysfunction of starvation, and may represent a protective component of the host response to inflammation.
Infection and inflammation-induced proatherogenic changes of lipoproteins.
- W. Khovidhunkit, R. Memon, K. Feingold, C. Grunfeld
- BiologyThe Journal of infectious diseases
- 1 June 2000
The changes of lipoproteins during infection and inflammation are reviewed with a focus on those that are potentially proatherogenic, which may contribute to the link between infection/inflammation and atherosclerosis.
Preclinical atherosclerosis due to HIV infection: carotid intima-medial thickness measurements from the FRAM study
The stronger association of HIV infection with IMT in the internal/bulb region compared with the common carotid may explain previous discrepancies in the literature and was similar to that of traditional CVD risk factors, such as smoking.