C. Grunfeld

Publications472
h-index99
Citations34,288
Highly Influential Citations1,016
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Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host.
Infection and inflammation induce the acute-phase response (APR), leading to multiple alterations in lipid and lipoprotein metabolism. Plasma triglyceride levels increase from increased VLDL… Expand
  • 1,072
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Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome.
Infection causes disturbances in lipid metabolism that may be mediated by cytokines. Therefore we studied plasma lipids, lipoproteins, triglyceride (TG) metabolism, and serum cytokines in three… Expand
  • 804
  • 38
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed… Expand
  • 1,740
  • 25
Association of tenofovir exposure with kidney disease risk in HIV infection
Objective:Despite widespread HAART use, HIV disease remains associated with increased risk of kidney disease. Whether tenofovir use is associated with higher risk of kidney disease is controversial.… Expand
  • 329
  • 25
Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters.
The expression of leptin, the ob gene product, is increased in adipose tissue in response to feeding and energy repletion, while leptin decreases food intake. Because adipose tissue gene expression… Expand
  • 876
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Management of Metabolic Complications Associated With Antiretroviral Therapy for HIV‐1 Infection: Recommendations of an International AIDS Society‐USA Panel
Objective: Alterations in glucose and lipid metabolism, lactic acidemia, bone disorders, and abnormal body fat distribution have been recognized recently as frequent complications associated with… Expand
  • 400
  • 22
  • PDF
Introduction to Lipids and Lipoproteins
  • 139
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Infection and inflammation-induced proatherogenic changes of lipoproteins.
Epidemiologic studies suggest a link between infection/inflammation and atherosclerosis. During the acute-phase response to infection and inflammation, cytokines induce tissue and plasma events that… Expand
  • 368
  • 18
Leptin regulation of the immune response and the immunodeficiency of malnutrition 1
Leptin is a 16 kDa protein mainly produced by adipose tissue in proportion to adipose tissue mass. Originally thought to be a satiety factor, leptin is a pleiotropic molecule. In addition to playing… Expand
  • 473
  • 15
Fat distribution and metabolic changes in patients with HIV infection.
Recent reports of localized areas of increased fat deposition and fat loss in HIV-infected patients, as well as changes in serum levels of metabolites and hormones, have led to the proposal that a… Expand
  • 358
  • 14