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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
MicroRNAs comprise a broad class of small non-coding RNAs that control expression of complementary target messenger RNAs. Dysregulation of microRNAs by several mechanisms has been described in… Expand
Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression.
The S/G2‐specific transcription of the human cdc25C gene is due to the periodic occupation of a repressor element (‘cell cycle‐dependent element’; CDE) located in the region of the basal promoter.… Expand
MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure.
BACKGROUND Chronic heart failure is characterized by left ventricular remodeling and reactivation of a fetal gene program; the underlying mechanisms are only partly understood. Here we provide… Expand
MicroRNAs in the Human Heart: A Clue to Fetal Gene Reprogramming in Heart Failure
Background— Chronic heart failure is characterized by left ventricular remodeling and reactivation of a fetal gene program; the underlying mechanisms are only partly understood. Here we provide… Expand
Cell cycle regulation of cdc25C transcription is mediated by the periodic repression of the glutamine-rich activators NF-Y and Sp1.
The late S/G2-specific transcription of the human cdc25C gene is dependent on an initiator-proximal repressor element (CDE) and an upstream activating sequence (UAS) of undefined nature. We now show… Expand
Hereditary vitamin D resistant rickets caused by a novel mutation in the vitamin D receptor that results in decreased affinity for hormone and cellular hyporesponsiveness.
- P. Malloy, T. R. Eccleshall, C. Gross, L. Van Maldergem, R. Bouillon, D. Feldman
- The Journal of clinical investigation
- 15 January 1997
Mutations in the vitamin D receptor (VDR) result in target organ resistance to 1alpha,25-dihydroxyvitamin D [1,25(OH)2D3], the active form of vitamin D, and cause hereditary 1,25-dihydroxyvitamin D… Expand
The differential binding of E2F and CDF repressor complexes contributes to the timing of cell cycle-regulated transcription.
- F. Lucibello, N. Liu, J. Zwicker, C. Gross, R. Mueller
- Medicine, Biology
- Nucleic acids research
- 1 December 1997
B- myb and cdc25C exemplify different groups of genes whose transcription is consecutively up-regulated during the cell cycle. Both promoters are controlled by transcriptional repression via modules… Expand
The pneumonectomy model of compensatory lung growth: insights into lung regeneration.
Pneumonectomy (PNX) in experimental animals leads to a species- and age-dependent compensatory growth of the remaining lung lobes. PNX mimics the loss of functional gas exchange units observed in a… Expand
Cell cycle regulated promoters for the targeting of tumor endothelium.
- D. Nettelbeck, J. Zwicker, +4 authors R. Mueller
- Medicine, Biology
- Advances in experimental medicine and biology
- 9 December 1998
Targeting of gene expression to tumors is one of the major challenges in cancer gene therapy. In this context both vector targeting and cell-specific transcription are of particular importance.… Expand
584 Prevention of cardiac hypertrophy and failure in vivo by a novel microRNA antagonist