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The sigma 70 family: sequence conservation and evolutionary relationships.
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Multiple sigma subunits and the partitioning of bacterial transcription space.
Promoter recognition in eubacteria is carried out by the initiation factor sigma, which binds RNA polymerase and initiates transcription. Cells have one housekeeping factor and a variable number ofExpand
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From the regulation of peptidoglycan synthesis to bacterial growth and morphology
How bacteria grow and divide while retaining a defined shape is a fundamental question in microbiology, but technological advances are now driving a new understanding of how the shape-maintainingExpand
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Quantifying Absolute Protein Synthesis Rates Reveals Principles Underlying Allocation of Cellular Resources
Quantitative views of cellular functions require precise measures of rates of biomolecule production, especially proteins-the direct effectors of biological processes. Here, we present a genome-wideExpand
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A collection of strains containing genetically linked alternating antibiotic resistance elements for genetic mapping of Escherichia coli.
We present a collection of 182 isogenic strains containing genetically linked antibiotic resistance elements located at approximately 1-min intervals around the Escherichia coli chromosome. At mostExpand
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Conserved and Variable Functions of the σE Stress Response in Related Genomes
Bacteria often cope with environmental stress by inducing alternative sigma (σ) factors, which direct RNA polymerase to specific promoters, thereby inducing a set of genes called a regulon to combatExpand
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Phenotypic Landscape of a Bacterial Cell
The explosion of sequence information in bacteria makes developing high-throughput, cost-effective approaches to matching genes with phenotypes imperative. Using E. coli as proof of principle, weExpand
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SurA, a periplasmic protein with peptidyl-prolyl isomerase activity, participates in the assembly of outer membrane porins.
Little is known about either the process of periplasmic protein folding or how information concerning the folding state in this compartment is communicated. We present evidence that SurA, aExpand
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Selective Ribosome Profiling Reveals the Cotranslational Chaperone Action of Trigger Factor In Vivo
As nascent polypeptides exit ribosomes, they are engaged by a series of processing, targeting, and folding factors. Here, we present a selective ribosome profiling strategy that enables globalExpand
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Bacterial sigma factors: a historical, structural, and genomic perspective.
Transcription initiation is the crucial focal point of gene expression in prokaryotes. The key players in this process, sigma factors (σs), associate with the catalytic core RNA polymerase to guideExpand
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