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Differential features of carotid and vertebral artery dissections
Objective: To examine whether risk factor profile, baseline features, and outcome of cervical artery dissection (CEAD) differ according to the dissection site. Methods: We analyzed 982 consecutiveExpand
Multiple Levels of Regulation of the Interleukin-6 System in Stroke
Background and Purpose— Serum levels of the cytokine interleukin-6 (IL-6) rise markedly in stroke. IL-6 is a key regulator of inflammatory mechanisms that play an important part in strokeExpand
Molecular analysis of aniridia patients for deletions involving the Wilms' tumor gene
A human aniridia candidate (AN) gene on chromosome 11p13 has been cloned and characterized. The AN gene is the second cloned gene of the contiguous genes syndrome WAGR (Wilms' tumor, aniridia,Expand
Pathogenesis of cervical artery dissections
Background: The etiology of spontaneous cervical artery dissection (CAD) is largely unknown. An underlying connective tissue disorder has often been postulated. Objective: To further assess theExpand
Cervical artery dissection
Objective: To examine the import of prior cervical trauma (PCT) in patients with cervical artery dissection (CeAD). Methods: In this observational study, the presence of and the type of PCT wereExpand
Evidence for infection with Chlamydia pneumoniae in a subgroup of patients with multiple sclerosis
In a pilot study, we identified Chlamydia pneumoniae in the cerebrospinal fluid by polymerase chain reaction in 5 of 10 patients with definite multiple sclerosis (MS). In a second series, 2 of 20Expand
A GLRA1 null mutation in recessive hyperekplexia challenges the functional role of glycine receptors.
Dominant missense mutations in the human glycine receptor (GlyR) alpha 1 subunit gene (GLRA1) give rise to hereditary hyperekplexia. These mutations impair agonist affinities and change conductanceExpand
Lipopolysaccharide receptor CD14 polymorphism and risk of stroke in a South-German population
Abstract.Background: The monocyte receptor for bacterial lipopolysaccharide CD14 is an important mediator of the inflammatory response. Recently, a polymorphism in the promotor of the CD14 gene, CExpand
Mutations in ROGDI Cause Kohlschütter-Tönz Syndrome.
Kohlschütter-Tönz syndrome (KTS) is an autosomal-recessive disease characterized by the combination of epilepsy, psychomotor regression, and amelogenesis imperfecta. The molecular basis has not yetExpand
Departure from Hardy Weinberg Equilibrium and Genotyping Error
Objective: Departure from Hardy Weinberg Equilibrium (HWE) may occur due to a variety of causes, including purifying selection, inbreeding, population substructure, copy number variation orExpand