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Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer.
TLDR
This study established the feasibility and safety of administering moderate doses of psilocybin to patients with advanced-stage cancer and anxiety and revealed a positive trend toward improved mood and anxiety. Expand
Human Psychopharmacology of Hoasca, A Plant Hallucinogen Used in Ritual Context in Brazil
TLDR
Assessment of 15 long-term members of a syncretic church that utilizes hoasca as a legal, psychoactive sacrament as well as 15 matched controls with no prior history of hoasca ingestion revealed high functional status. Expand
Psychobiologic effects of 3,4-methylenedioxymethamphetamine in humans: methodological considerations and preliminary observations
TLDR
The background, methodology and preliminary findings of the first FDA approved Phase I study prospectively evaluating the effects of MDMA administration in humans, using a randomized, double-blind methodologic design are discussed. Expand
Pharmacokinetics of Hoasca alkaloids in healthy humans.
TLDR
N,N-Dimethyltryptamine, harmine, harmaline and tetrahydroharmine are the characteristic alkaloids found in Amazonian sacraments known as hoasca, ayahuasca, and yajè and little is known of their pharmacokinetics. Expand
Enlarged striatum in abstinent methamphetamine abusers: A possible compensatory response
TLDR
Since METH subjects with larger striatal structures had relatively normal cognitive performance and lesser cumulative METH usage, the enlarged putamen and globus pallidus might represent a compensatory response to maintain function. Expand
An emergency department intervention for linking pediatric suicidal patients to follow-up mental health treatment.
TLDR
Results support efficacy of the enhanced emergency department intervention for improving linkage to outpatient mental health treatment but underscore the need for improved community outpatient treatment to prevent suicide, suicide attempts, and poor clinical and functioning outcomes for suicidal youths treated in emergency departments. Expand
Quantitation of N,N-dimethyltryptamine and harmala alkaloids in human plasma after oral dosing with ayahuasca.
TLDR
The one-step extraction method for DMT and the protein precipitation method for the three harmala alkaloid afford rapid, sensitive, and quantitative analyses of these alkaloids with minimal analyte loss. Expand
Effect of ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] on cerebral blood flow: a co-registered SPECT and MRI study
TLDR
Abstinent MDMA users showed no significantly different global or regional CBF (rCBF) compared to the control subjects, but within 3 weeks after MDMA administration, rCBF remained decreased in the visual cortex, the caudate, the superior parietal and dorsolateral frontal regions compared to baseline r CBF. Expand
Novel psychopharmacological therapies for psychiatric disorders: psilocybin and MDMA.
TLDR
4-phosphorloxy-N,N-dimethyltryptamine (psilocybin) and methylenedioxymethamfetamine (MDMA) are showing promise as therapeutics in a resurgence of clinical research during the past 10 years. Expand
Cerebral 1H MRS alterations in recreational 3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) users
TLDR
The usage‐related increase in MI suggests that exposure to MDMA, even at recreational doses, may cause increased glial content, and the normal NA concentration suggests a lack of significant neuronal injury in recreational MDMA users. Expand
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