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Synthesis and Immunological Characterization of Toll-Like Receptor 7 Agonistic Conjugates
Activation of toll-like receptors (TLRs) on cells of the innate immune system initiates, amplifies, and directs the antigen-specific acquired immune response. Ligands that stimulate TLRs, therefore,Expand
Synthesis and characterization of PEGylated toll like receptor 7 ligands.
Toll-like receptor 7 (TLR7) is located in the endosomal compartment of immune cells. Signaling through TLR7, mediated by the adaptor protein MyD88, stimulates the innate immune system and shapesExpand
Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7
Activation of Toll-like receptors (TLR) contributes to the initiation and maintenance of chronic inflammation in autoimmune diseases, yet repeated exposure to a TLR agonist can induceExpand
Treatment of Autoimmune Inflammation by a TLR7 Ligand Regulating the Innate Immune System
The Toll-like receptors (TLR) have been advocated as attractive therapeutic targets because TLR signaling plays dual roles in initiating adaptive immune responses and perpetuating inflammation.Expand