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Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma
Temozolomide (TMZ) is an alkylating agent used for the treatment of glioblastoma multiforme (GBM), the main form of human brain tumours in adults. It has been reported that TMZ induced DNA lesionsExpand
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Retinoid acid supports granulocytic but not erythroid differentiation of myeloid progenitors in normal bone marrow cells.
In the new context of the use of retinoic acid (RA) therapy as an inducer of leukemic differentiation and a selective inhibitor of human myeloid leukemia cell growth, we undertook to explore theExpand
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Justicidin B, a cytotoxic principle from Justicia pectoralis.
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Reciprocal protection of Mcl-1 and Bim from ubiquitin-proteasome degradation.
Survival of multiple myeloma cells is essentially dependent on Mcl-1 protein that neutralizes the pro-apoptotic function of Bim and prevents activation of death effectors. To clarify the relationshipExpand
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Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity
Purpose: Glioblastoma (GBM) is the most common and malignant form of primary human brain tumor in adults, with an average survival at diagnosis of 18 months. Metabolism is a new attractiveExpand
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Dietary prevention of malignant glioma aggressiveness, implications in oxidant stress and apoptosis
Our study explored the influence of diet on gliomagenesis and associated systemic effects (SE) in rats. The experimental diet contained various ingredients supposed to interfere with carcinogenesis,Expand
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D-2-Hydroxyglutarate does not mimic all the IDH mutation effects, in particular the reduced etoposide-triggered apoptosis mediated by an alteration in mitochondrial NADH
Somatic mutations in isocitrate dehydrogenase (IDH)-1 and -2 have recently been described in glioma. This mutation leads to a neomorphic enzymatic activity as the conversion of isocitrate to alphaExpand
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Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma
Drug resistance limits the therapeutic efficacy in cancers and leads to tumor recurrence through ill-defined mechanisms. Glioblastoma (GBM) are the deadliest brain tumors in adults. GBM, at diagnosisExpand
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Assignment1 of the BRCA1-associated RING domain gene (Bard1) to rat chromosome 9q34 by in situ hybridization and radiation hybrid mapping
The BRCA1-associated RING domain protein 1, BARD1 (Wu et al., 1996), is supposed to play a critical role in BRCA1mediated tumor suppression. Inhibition of BARD1 expression in cultured cells resultsExpand
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Impairing temozolomide resistance driven by glioma stem‐like cells with adjuvant immunotherapy targeting O‐acetyl GD2 ganglioside
Stem cell chemoresistance remains challenging the efficacy of the front‐line temozolomide against glioblastoma. Novel therapies are urgently needed to fight those cells in order to control tumorExpand
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