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Essential fatty acid deficiency and postresection mucosal adaptation in the rat.
The effect of short-term (biochemical) and long-term (clinical) essential fatty acid (EFA) deficiency on mucosal adaptation was studied in a surgical model of short bowel syndrome. Rats fed anExpand
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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced decrease in the fluidity of rat liver membranes.
1. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCCD)-induced lipid peroxidation has previously been demonstrated by assessing the hepatic content of thiobarbituric acid reactive substances (TBARS) as wellExpand
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Effects of isolated zinc deficiency on the composition of skeletal muscle, liver and bone during growth in rats.
We investigated the effects of zinc deficiency on body composition by using intragastric force-feeding to obviate decreased food intake and altered eating patterns. Weanling male Sprague-Dawley ratsExpand
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Reduced mucosal prostaglandin synthesis after massive small bowel resection.
Exogenous 16,16-di-methyl-prostaglandin (PG) E2 administration augments mucosal hyperplasia after massive small bowel resection in the rat. We, therefore, evaluated the ability of aspirin to inhibitExpand
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Effects of dietary linoleic acid on mucosal adaptation after small bowel resection.
We have shown that dietary long-chain triglycerides and 16,16-dimethyl prostaglandin E2 enhance and aspirin impairs postresection mucosal adaptation in rats. The present studies examined theExpand
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Transplacental effect of nitrosamines in Syrian hamsters
The present investigations showed that assumed and established metabolites of dipropylnitrosamine and dibutylnitrosamine reach the Syrian hamster fetus after subcutaneous (s.c.) treatment of theirExpand
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Diallylnitrosamine: a potent respiratory carcinogen in Syrian golden hamsters: brief communication.
Diallylnitrosamine (DAN), one of the few nitrosamines tested thus far that has not induced neoplasms in rats, caused a high incidence of respiratory tract tumors in Syrian golden hamsters treated scExpand
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Carcinogenicity of N-nitrosomethyl(2-oxopropyl)amine in Syrian hamsters.
7-Methylguanine was found in hydrolysates of liver and pancreas DNA from Syrian golden hamsters given a single dose of N-[1-14C]nitrosobis(2-oxopropyl)amine (BOP). This led us to examine theExpand
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Vinylethylnitrosamine: a potent respiratory carcinogen in Syrian hamsters.
Vinylethylnitrosamine (VEN), an alpha-beta unsaturated analogue of diethylnitrosamine (DEN), which may be formed by the enzymic conversion necessary for carcinogenesis, was synthesized and itsExpand
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The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo.
After injection of N-nitrosobis(2-oxopropyl)amine (BOP) (10 mg/kg) to male Syrian golden hamsters there were there concentrations of BOP and many of its metabolites in the hamster pancreas comparedExpand
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