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The use of sea urchin eggs as a model to investigate the effects of crassolide, a diterpene isolated from a soft coral.
Crassolide, a monocyclic diterpene isolated and purified from the soft coral Lobophytum crassum, inhibited the cell cleavage of sea urchin eggs without affecting fertilization and could be used as a negative control when analysing calcium changes in short-term toxicological studies. Expand
Stage-specific effects of teratogens on sea urchin embryogenesis.
Using sea urchin embryos to detect and analyze the early mechanisms of teratogenic action revealed that post-hatching exposure to allopurinol failed to affect the embryogenesis and the indirect teratogen cyclophosphamide had no effect on the early embryogenesis. Expand
Embryotoxic potency of 2,4,5-trichlorophenoxyacetic acid on sea urchin eggs: Association with calcium homoeostasis.
  • C. Graillet, J. Girard
  • Biology, Medicine
  • Toxicology in vitro : an international journal…
  • 1 October 1994
The results suggest that the teratogenic potency of 2,4,5-T is associated with delay in first cleavages and alterations in Ca(2+) homoeostasis, similar to those producing embryonic abnormalities and lethality. Expand
A drug-induced change in the Ca2+ storage capacity of sea urchin eggs resulting in retardation of cleaving stages and in further developmental defects is discussed in view to the possibility of relating changes in Ca2-homeostasis with teratogenicity. Expand
Alteration of Ca2+ homeostasis of sea urchin embryos by retinoid CD 367, dual effect on egg cleavage and embryonic development.
Since the authors were unable to detect nuclear receptors for CD 367 in sea urchin eggs and ovocytes, these effects probably are not related to interaction of the retinoid with members of the RAR family, but rather to its toxicity by the means of some unknown mechanisms. Expand