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The cognitive neuroscience of ageing
- C. Grady
- PsychologyNature Reviews Neuroscience
- 1 July 2012
Current trends and unresolved issues in the cognitive neuroscience of ageing are discussed and it is less clear how age differences in brain activity relate to cognitive performance.
Spatial Pattern Analysis of Functional Brain Images Using Partial Least Squares
Partial least squares serves as an important extension by extracting new information from imaging data that is not accessible through other currently used univariate and multivariate image analysis tools.
Event-related fMRI studies of episodic encoding and retrieval: Meta-analyses using activation likelihood estimation
Age-related changes in cortical blood flow activation during visual processing of faces and location
The results demonstrate that reliable age-related changes during visual processing can be found in rCBF patterns, suggesting more efficient use of occipital visual areas by younger subjects and more reliance by older subjects on one or more cortical networks, particularly for spatial vision, perhaps to compensate for reduced processing efficiency of Occipital cortex.
Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory
The evidence suggests strongly that the function of the hippocampus (and possibly that of related limbic structures) is to help encode, retain, and retrieve experiences, no matter how long ago the events comprising the experience occurred, and no matter whether the memories are episodic or spatial.
The functional organization of human extrastriate cortex: a PET-rCBF study of selective attention to faces and locations
- J. Haxby, B. Horwitz, Leslie G. Ungerleider, J. Maisog, P. Pietrini, C. Grady
- Biology, PsychologyJournal of Neuroscience
- 1 November 1994
The functional dissociation of human extrastriate cortical processing streams for the perception of face identity and location was investigated in healthy men by measuring visual task-related changes…
Age-Related Differences in Neural Activity during Memory Encoding and Retrieval: A Positron Emission Tomography Study
The results indicate that advanced age is associated with neural changes in the brain systems underlying encoding, recognition, and recall that take two forms: age- related decreases in local regional activity, which may signal less efficient processing by the old, and age-related increases in activity,Which may signal functional compensation.
In search of the emotional self: an fMRI study using positive and negative emotional words.
By providing a personal perspective in the evaluation of emotional stimuli, the right dorsomedial prefrontal cortex may mediate cognitive processes, such as those involved in psychotherapy, that guide self-regulation of emotional experience.
Dissociation of object and spatial visual processing pathways in human extrastriate cortex.
- J. Haxby, C. Grady, S. Rapoport
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 1 March 1991
The ventral and dorsal locations of the regions specialized for object recognition and spatial localization, respectively, suggest some homology between human and nonhuman primate extrastriate cortex, with displacement in human brain, possibly related to the evolution of phylogenetically newer cortical areas.
Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network
The DMN supports common aspects of these cognitive behaviors involved in simulating an internalized experience, including autobiographical remembering, prospection, and theory-of-mind reasoning.