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Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions.
We report that coactivator SAGA, containing the HAT Gcn5p, occupies the GAL1 and ARG1 coding sequences during transcriptional induction, dependent on PIC assembly and Ser5 phosphorylation of the PolExpand
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Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes.
Methylation of histone H3 by Set1 and Set2 is required for deacetylation of nucleosomes in coding regions by histone deacetylase complexes (HDACs) Set3C and Rpd3C(S), respectively. We report thatExpand
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Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2.
Gene transcription, RNA biogenesis, and mRNA transport constitute a complicated process essential for all eukaryotic cells. The transcription/export factor Sus1 plays a key role in couplingExpand
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Diverse fiber composition of swimming muscles in the blue crab, Callinectes sapidus
The gross morphology and histochemistry of basal swimming muscles of the fifth pereiopod of the blue crab, Callinectes sapidus, were investigated. Each of the major muscles has two to three discreteExpand
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NuA4 Lysine Acetyltransferase Esa1 Is Targeted to Coding Regions and Stimulates Transcription Elongation with Gcn5
ABSTRACT NuA4, the major H4 lysine acetyltransferase (KAT) complex in Saccharomyces cerevisiae, is recruited to promoters and stimulates transcription initiation. NuA4 subunits contain domains thatExpand
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Simultaneous Recruitment of Coactivators by Gcn4p Stimulates Multiple Steps of Transcription In Vivo
ABSTRACT Transcriptional activation by Gcn4p is dependent on the coactivators SWI/SNF, SAGA, and Srb Mediator, which are recruited by Gcn4p and stimulate assembly of the preinitiation complex (PIC)Expand
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cis-requirement for the maintenance of round spermatid-specific transcription.
Maintenance of strict developmental stage- and cell type-specific gene expression is critical for the progression of spermatogenesis. However, the mechanisms which sustain the spatiotemporal order ofExpand
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Recruitment of the ArgR/Mcm1p repressor is stimulated by the activator Gcn4p: a self-checking activation mechanism.
Transcription of the arginine biosynthetic gene ARG1 is repressed by the ArgR/Mcm1p complex in arginine-replete cells and activated by Gcn4p, a transcription factor induced by starvation for anyExpand
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Contractile proteins of fast and slow fibers during differentiation of lobster claw muscle.
Contractile protein populations were determined, using gel electrophoresis, during development of the claw closer muscles of the lobster Homarus americanus. In the adult the paired claw closerExpand
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Asymmetry in Lobster Claws
1 he external body plan of higher animals from annelids to primates is that of bilateral symmetry, in which the left half of the body is a mirror image of the right half. Often superimposed upon thisExpand
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