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In vitro effects of silver nanoparticles on the mitochondrial respiratory chain
TLDR
It is demonstrated that AgN (10, 25, and 50 mg l−1) decreases the activity of mitochondrial respiratory chain complexes I, II, III, and IV from all tissues.
Doxorubicin caused severe hyperglycaemia and insulin resistance, mediated by inhibition in AMPk signalling in skeletal muscle
TLDR
It was observed that treatment with DOX increased the systemic insulin resistance and caused a massive increase in glucose levels in serum, and involvement of AMPk signalling in skeletal muscle in this process was assessed.
Acute administration of ketamine reverses the inhibition of mitochondrial respiratory chain induced by chronic mild stress
TLDR
It is hypothesized that CMS induces inhibition of mitochondrial respiratory chain (complexes I, III and IV) and that acute administration of ketamine reverses such effect and it is verified that CMS decreased the intake of sweet food and ketamine was not able to reverse such effect.
Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression
TLDR
Although it is difficult to extrapolate the findings to the human condition, the inhibition of mitochondrial respiratory chain by chronic stress may be one mechanism in the pathophysiology of depressive disorders.
Effects of mood stabilizers on mitochondrial respiratory chain activity in brain of rats treated with d-amphetamine.
TLDR
It is suggested that dopamine can be an important link for the mitochondrial dysfunction seen in BD and, Li and VPA exert protective effects against this d-AMPH-induced mitochondrial dysfunction, but this effect varies depending on the brain region and the treatment regimen.
Skeletal muscle electron transport chain dysfunction after sepsis in rats.
TLDR
The results suggest that quadriceps mitochondria are more resistant to sepsis-induced dysfunction, which seemed to be secondary to early oxidative stress and correlates with diaphragm contractile strength.
Non-Nucleoside Reverse Transcriptase Inhibitors Efavirenz and Nevirapine Inhibit Cytochrome C Oxidase in Mouse Brain Regions
TLDR
It is observed that the complex IV activity was inhibited by both EFV and NVP in cerebral cortex, striatum and hippocampus of mice, but not in cerebellum, as compared to control group, and speculated that brain energy metabolism dysfunction could be involved in the CNS-related adverse effects.
Omega-3 fatty acids alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration
TLDR
Investigation of the effects of ω3 fatty acids on locomotor behavior and oxidative stress parameters in brain of rats subjected to an animal model of mania induced by fenproporex demonstrated that fenProporex-induced hyperlocomotion and damage through oxidative stress were prevented.
Effects of N-Acetylcysteine/Deferoxamine, Taurine and RC-3095 on Respiratory Chain Complexes and Creatine Kinase Activities in Rat Brain After Sepsis
TLDR
It was demonstrated that CLP inhibited complexes I and II, and that all the treatments were able to reverse this inhibition in all brain areas studied in the present work, which showed beneficial effects of the treatments proposed.
Mitochondria and the central nervous system: searching for a pathophysiological basis of psychiatric disorders.
TLDR
Evidence suggests that alterations in mitochondrial morphology, brain energy metabolism, and mitochondrial enzyme activity may be involved in the pathophysiology of different neuropsychiatric disorders, given their key role in energy metabolism in the cell.
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