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Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.
A G protein-coupled receptor for the pineal hormone melatonin was recently cloned from mammals and designated the Mel1a melatonin receptor. We now report the cloning of a second G protein-coupledExpand
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Melatonin receptors step into the light: cloning and classification of subtypes.
Melatonin, the principal hormone of the pineal gland, has several biological effects’. The hormone regulates the repwlustive alterations that occur in response to chaqges in day length in seasonallyExpand
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Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.
Hypoxia is a feature of the microenvironment of a growing tumor. The transcription factor NFkappaB is activated in hypoxia, an event that has significant implications for tumor progression. Here, weExpand
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Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity
Hypoxia is a feature of the microenvironment of a growing tumor. The transcription factor NFκB is activated in hypoxia, an event that has significant implications for tumor progression. Here, weExpand
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Melatonin receptors are for the birds: Molecular analysis of two receptor subtypes differentially expressed in chick brain
Two receptors (CKA and CKB) of the G protein-coupled melatonin receptor family were cloned from chick brain. CKA encodes a protein that is 80% identical at the amino acid level to the human Mel1aExpand
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Leukotriene B4/antimicrobial peptide LL‐37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A4 and resolvin E1
In humans, the antimicrobial peptide LL‐37 and leukotriene B4 (LTB4) are important proinflammatory mediators, whereas lipoxin A4 (LXA4) and resolvin E1 (RvE1) possess anti‐inflammatory, prore‐solvingExpand
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The Mel1a melatonin receptor is coupled to parallel signal transduction pathways.
The recent cloning of a family of high affinity melatonin receptors has provided us with a unique opportunity to define the signal transduction pathways used by these receptors. We have studiedExpand
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Lipoxins: endogenous regulators of inflammation.
  • B. McMahon, C. Godson
  • Medicine, Biology
  • American journal of physiology. Renal physiology
  • 1 February 2004
Over the past decade, compelling in vivo and in vitro studies have highlighted lipoxins (LXs) and aspirin-triggered LXs (ATLs) as endogenously produced anti-inflammatory eicosanoids. LXs and ATLsExpand
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Lipoxins: revelations on resolution.
Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell-cell interactions. In this article, the compelling evidence from in vitro and in vivo model systems that LXsExpand
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High Glucose-altered Gene Expression in Mesangial Cells
High extracellular glucose plays a pivotal role in the pathophysiology of diabetic nephropathy. Here we report 200 genes, identified using suppression-subtractive hybridization, that areExpand
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