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Significance of Respirasomes for the Assembly/Stability of Human Respiratory Chain Complex I*
- H. Schägger, R. de Coo, M. Bauer, S. Hofmann, C. Godinot, U. Brandt
- Biology, Medicine
- Journal of Biological Chemistry
- 27 August 2004
We showed that the human respiratory chain is organized in supramolecular assemblies of respiratory chain complexes, the respirasomes. The mitochondrial complexes I (NADH dehydrogenase) and III… Expand
Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma.
A mechanism decreasing oxidative metabolism during normal cell division and growth is expected to direct substrates toward biosyntheses rather than toward complete oxidation to CO(2). Hence, any… Expand
Functional F1-ATPase essential in maintaining growth and membrane potential of human mitochondrial DNA-depleted rho degrees cells.
F1-ATPase assembly has been studied in human rho degrees cells devoid of mitochondrial DNA (mtDNA). Since, in these cells, oxidative phosphorylation cannot provide ATP, their growth relies on… Expand
Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma.
- G. Gasparre, E. Hervouet, +14 authors H. Simonnet
- Medicine, Biology
- Human molecular genetics
- 1 April 2008
Mutations in mitochondrial DNA (mtDNA) are frequent in cancers but it is not yet clearly established whether they are modifier events involved in cancer progression or whether they are a consequence… Expand
Mitochondrial complex I is deficient in renal oncocytomas.
Renal oncocytomas are benign tumors characterized by dense accumulation of mitochondria the cause of which remains unknown so far. Consistently, mitochondrial DNA content and the amounts and… Expand
Functional F1-ATPase Essential in Maintaining Growth and Membrane Potential of Human Mitochondrial DNA-depleted ρ° Cells*
F1-ATPase assembly has been studied in human ρ° cells devoid of mitochondrial DNA (mtDNA). Since, in these cells, oxidative phosphorylation cannot provide ATP, their growth relies on glycolysis.… Expand
Pig heart mitochondrial ATPase : properties of purified and membrane-bound enzyme. Effects of flavonoids.
Soluble ATPase (F1) has been purified from pig heart mitochondria. The purified enzyme had a high specific activity and was homogeneous as checked by ultracentrifugation and electrofocusing. It could… Expand
HIF and reactive oxygen species regulate oxidative phosphorylation in cancer.
A decrease in oxidative phosphorylation (OXPHOS) is characteristic of many cancer types and, in particular, of clear cell renal carcinoma (CCRC) deficient in von Hippel-Lindau (vhl) gene. In the… Expand
Leigh‐like encephalopathy complicating Leber's hereditary optic neuropathy
Leber's hereditary optic neuropathy is a mitochondrial disease caused by point mutations in mitochondrial DNA. It usually presents as severe bilateral visual loss in young adults. We report on a… Expand
Tissue and skeletal changes in the scleractinian coral Stylophora pistillata Esper 1797 under phosphate enrichment
article i nfo Long-term phosphate enrichments (0, 0.5, and 2.5 μmol L − 1 ; 4 to 11 weeks) were used to assess a possible limitation in phosphorus of zooxanthellae and to complement data on the… Expand