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Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis.
Treatment with beta carotene, vitamin A, vitamin E, and vitamin E may increase mortality and the potential roles of vitamin C and selenium on mortality need further study. Expand
Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study
The average bias associated with defects in the conduct of randomised trials varies with the type of outcome, andSystematic reviewers should routinely assess the risk of bias in the results of trials, and should report meta-analyses restricted to trials at low risk of biases. Expand
Reported Methodologic Quality and Discrepancies between Large and Small Randomized Trials in Meta-Analyses
The potential association between reported methodologic quality and intervention effects was studied to assess whether methodologicquality may explain discrepancies between the results of large and small randomized trials in meta-analyses. Expand
Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis.
TSA may establish when firm evidence is reached in meta-analysis, and six randomly selected neonatal meta-analyses showed early potentially spurious P<0.05 values, establishing firm evidence of an intervention effect. Expand
Treatment of deep caries lesions in adults: randomized clinical trials comparing stepwise vs. direct complete excavation, and direct pulp capping vs. partial pulpotomy.
Stepwise excavation decreases the risk of pulp exposure compared with direct complete excavation, and in view of the poor prognosis of vital pulp treatment, a stepwise excavation approach for managing deep caries lesions is recommended. Expand
Influence of Reported Study Design Characteristics on Intervention Effect Estimates From Randomized, Controlled Trials
For each characteristic, average bias and increases in between-trial heterogeneity were driven primarily by trials with subjective outcomes, with little evidence of bias in trials with objective and mortality outcomes. Expand
Off-pump versus on-pump coronary artery bypass grafting for ischaemic heart disease.
A systematic review did not demonstrate any significant benefit of off-pump compared with on-p Pump CABG regarding mortality, stroke, or myocardial infarction, but observed better long-term survival in the group of patients undergoing on- pump CabG with the use of cardiopulmonary bypass and cardioplegic arrest. Expand
Randomised clinical trials of fish oil supplementation in high risk pregnancies
Objective To test the postulated preventive effects of dietary n‐3 fatty acids on pre‐term delivery, intrauterine growth retardation, and pregnancy induced hypertension.
The DEMO trial: a randomized, parallel-group, observer-blinded clinical trial of strength versus aerobic versus relaxation training for patients with mild to moderate depression.
The findings do not support a biologically mediated effect of exercise on symptom severity in depressed patients, but they do support a beneficial effect of strength training on work capacity. Expand
Antihypertensive drugs and risk of cancer: network meta-analyses and trial sequential analyses of 324,168 participants from randomised trials.
This analysis refutes a 5·0-10·0% relative increase in the risk of cancer or cancer-related death with the use of ARBs, ACEi, β blockers, diuretics, and CCBs. Expand