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The Neurometabolic Cascade of Concussion.
OBJECTIVE: To review the underlying pathophysiologic processes of concussive brain injury and relate these neurometabolic changes to clinical sports-related issues such as injury to the developing… Expand
Consensus statement on concussion in sport—the 5th international conference on concussion in sport held in Berlin, October 2016
The 2017 Concussion in Sport Group (CISG) consensus statement is designed to build on the principles outlined in the previous statements1–4 and to develop further conceptual understanding of… Expand
The molecular pathophysiology of concussive brain injury.
Concussion or mild traumatic brain injury (mTBI) is a condition that affects hundreds of thousands of patients worldwide. Understanding the pathophysiology of this disorder can help manage its acute… Expand
Summary of evidence-based guideline update: Evaluation and management of concussion in sports
Objective: To update the 1997 American Academy of Neurology (AAN) practice parameter regarding sports concussion, focusing on 4 questions: 1) What factors increase/decrease concussion risk? 2) What… Expand
The new neurometabolic cascade of concussion.
Since the original descriptions of postconcussive pathophysiology, there has been a significant increase in interest and ongoing research to study the biological underpinnings of concussion. The… Expand
The New Neurometabolic Cascade of Concussion.
Objective: To review the underlying pathophysiologic processes of concussive brain injury and relate these neurometabolic changes to clinical sports-related issues such as injury to the developing… Expand
The pathophysiology of traumatic brain injury at a glance
- M. Prins, T. Greco, D. Alexander, C. Giza
- Medicine, Biology
- Disease Models & Mechanisms
- 12 September 2013
Traumatic brain injury (TBI) is defined as an impact, penetration or rapid movement of the brain within the skull that results in altered mental state. TBI occurs more than any other disease,… Expand
Glutamate and GABA Imbalance Following Traumatic Brain Injury
- Rejean M Guerriero, C. Giza, A. Rotenberg
- Current Neurology and Neuroscience Reports
- 22 March 2015
Traumatic brain injury (TBI) leads to multiple short- and long-term changes in neuronal circuits that ultimately conclude with an imbalance of cortical excitation and inhibition. Changes in… Expand
Concussive Brain Injury Enhances Fear Learning and Excitatory Processes in the Amygdala
- Maxine L Reger, A. Poulos, F. Buen, C. Giza, M. Fanselow
- Medicine, Psychology
- Biological Psychiatry
- 15 February 2012
BACKGROUND Mild traumatic brain injury (cerebral concussion) results in cognitive and emotional dysfunction. These injuries are a significant risk factor for the development of anxiety disorders,… Expand
The Molecular Pathophysiology of Concussive Brain Injury - an Update.
- G. Barkhoudarian, D. Hovda, C. Giza
- Physical medicine and rehabilitation clinics of…
- 1 May 2016
Concussion, or mild traumatic brain injury (TBI), affects millions of patients worldwide. Understanding the pathophysiology of TBI can help manage its repercussions. The brain is significantly… Expand