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Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes.
Neutralization of the normally acidic stratum corneum (SC) has deleterious consequences for permeability barrier homeostasis and SC integrity/cohesion attributable to serine proteases (SPs)Expand
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Cannabinoid receptors 1 and 2 oppositely regulate epidermal permeability barrier status and differentiation
Cannabinoid receptors (CBR) 1 and 2 have been implicated in keratinocyte differentiation/proliferation. How CB receptors affect epidermal permeability barrier and stratum corneum structure andExpand
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The role of endothelial cells in the vasculopathy of systemic sclerosis: A systematic review.
INTRODUCTION Systemic sclerosis (SSc) is an autoimmune connective tissue disorder characterized by fibroproliferative vasculopathy, immunological abnormalities and progressive fibrosis of multipleExpand
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The "caveolae brake hypothesis" and the epidermal barrier.
Epidermal permeability barrier formation depends upon lamellar body (LB) secretion/fusion with the apical plasma membrane (APM) of outermost stratum granulosum (SG) cell, creatingExpand
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Impact of rifting and hydrography on the genetic structure of Clarias gariepinus in Eastern Africa
In a study of the genetic structure of Clarias gariepinus at the ND5 and ND6 loci of mitochondrial DNA using RFLP-PCR in 16 populations (267 fish), a total of 18 haplotypes was detected. The mostExpand
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Actin dynamics regulate immediate PAR-2-dependent responses to acute epidermal permeability barrier abrogation.
BACKGROUND Lamellar body (LB) secretion and terminal differentiation of stratum granulosum (SG) cells are signaled by both protease activated receptor-2 (PAR-2) and caveolin-1 (cav-1). OBJECTIVE ToExpand
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Lipid Rafts and Caveolae in the Terminal Differentiation of Epidermal Keratinocytes
Lipid rafts are cholesterol and sphingolipid-enriched plasma membrane domains, Caveolae represent a subclass of lipid rafts and the chief structural proteins are caveolins (caveolin-1, -2 and -3).Expand
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