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Menthol: a natural analgesic compound
Menthol, after topical application, causes a feeling of coolness due to stimulation of 'cold' receptors by inhibiting Ca++ currents of neuronal membranes. Since Ca++ channel blockers are endowed withExpand
Glial role in oxaliplatin-induced neuropathic pain
Oxaliplatin, a platinum-based chemotherapeutic agent, has become a standard treatment for advanced colorectal cancer. The dose-limiting toxicity of this compound is the development of peripheralExpand
Development, characterization and in vivo evaluation of benzocaine-loaded liposomes.
This study reports the development and in vivo evaluation of a liposomal formulation of the local anaesthetic benzocaine. Multi-lamellar (MLV) and small uni-lamellar (SUV) vesicles entrappingExpand
Role of histamine in rodent antinociception
1 Effects of substances which are able to alter brain histamine levels on the nociceptive threshold were investigated in mice and rats by means of tests inducing three different kinds of noxiousExpand
Signaling pathway of morphine induced acute thermal hyperalgesia in mice
Abstract Systemic administration of morphine induced a hyperalgesic response in the hot plate test, at an extremely low dose (1–10 μg/kg). We have examined in vivo whether morphine, at an extremelyExpand
Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism
Neuropathic syndromes which are evoked by lesions to the peripheral or central nervous system are extremely difficult to treat, and available drugs rarely joint an antihyperalgesic with aExpand
Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype
The activation of alpha2-adrenoceptors has been reported to impair memory functions in both rats and humans. The alpha2-adrenoceptor subtype responsible for this detrimental effect is still unknown.Expand
Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes.
The administration of the ryanodine receptor (RyR) agonist 4-Cmc (0.003-9 nmol per mouse intracerebroventricularly [i.c.v.]) ameliorated memory functions, whereas the RyR antagonist ryanodineExpand
Effect of preparation technique on the properties and in vivo efficacy of benzocaine-loaded ethosomes
This study aimed to investigate the influence of the preparation conditions on the performance of an ethosomal formulation for topical delivery of the local anesthetic agent, benzocaine (BZC).Expand
Effect of potassium channel modulators in mouse forced swimming test
The effect of intracerebroventricular (i.c.v.) administration of different potassium channel blockers (tetraethylammonium, apamin, charybdotoxin, gliquidone), potassium channel openers (pinacidil,Expand