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Menthol: a natural analgesic compound
Glial role in oxaliplatin-induced neuropathic pain
Development, characterization and in vivo evaluation of benzocaine-loaded liposomes.
Role of histamine in rodent antinociception
- P. Malmberg-Aiello, C. Lamberti, C. Ghelardini, A. Giotti, A. Bartolini
- Biology, MedicineBritish journal of pharmacology
- 1 April 1994
Effects of substances which are able to alter brain histamine levels on the nociceptive threshold were investigated in mice and rats by means of tests inducing three different kinds of noxious stimuli: mechanical (paw pressure), chemical (abdominal constriction) and thermal (hot plate) and l‐Histidine HCl dose‐dependently induced a slowly occurring antinociception.
Effect of preparation technique on the properties and in vivo efficacy of benzocaine-loaded ethosomes
- F. Maestrelli, G. Capasso, M. L. González-Rodríguez, A. Rabasco, C. Ghelardini, P. Mura
- BiologyJournal of liposome research
- 28 October 2009
The overall results suggest that a suitably developed ethosomal formulation of BZC can be of actual value for improving its clinical effectiveness in topical anesthesia.
Signaling pathway of morphine induced acute thermal hyperalgesia in mice
Role of 5-HT4 receptors in the mouse passive avoidance test.
- N. Galeotti, C. Ghelardini, A. Bartolini
- Biology, PsychologyThe Journal of pharmacology and experimental…
- 1 September 1998
The results suggest that the modulation of 5-HT4 receptors plays an important role in the regulation of memory processes and the 5- HT4 receptor antagonists may represent pharmacological tools for investigation of new potential antiamnesic drugs.
Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism
- L. di Cesare Mannelli, G. D'Agostino, A. Calignano
- Biology, MedicineMediators of inflammation
- 25 February 2013
Results strongly suggest that PEA, via a PPAR-α-mediated mechanism, can directly intervene in the nervous tissue alterations responsible for pain, starting to prevent macrophage infiltration.
Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype
Effect of potassium channel modulators in mouse forced swimming test
- N. Galeotti, C. Ghelardini, Bernardetta Caldari, A. Bartolini
- BiologyBritish journal of pharmacology
- 1 April 1999
Results suggest that modulation of potassium channels plays an important role in the regulation of immobility time in the mouse forced swimming test, and that potassium channels modulators and the mKv1.c.1 aODN did not impair motor coordination, as revealed by the rota rod test.