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Surface Studies by Scanning Tunneling Microscopy
Surface microscopy using vacuum tunneling is demonstrated for the first time. Topographic pictures of surfaces on an atomic scale have been obtained. Examples of resolved monoatomic steps and surface…
Translating biomolecular recognition into nanomechanics.
The specific transduction, via surface stress changes, of DNA hybridization and receptor-ligand binding into a direct nanomechanical response of microfabricated cantilevers is reported, demonstrating the wide-ranging applicability of nanomechamical transduction to detect biomolecular recognition.
Tunneling through a controllable vacuum gap
We report on the first successful tunneling experiment with an externally and reproducibly adjustable vacuum gap. The observation of vacuum tunneling is established by the exponential dependence of…
7 × 7 Reconstruction on Si(111) Resolved in Real Space
The 7× 7 reconstruction on Si(111) was observed in real space by scanning tunneling microscopy. The experiment strongly favors a modified adatom model with 12 adatoms per unit cell and an…
Reproducible switching effect in thin oxide films for memory applications
Thin oxide films with perovskite or related structures and with transition metal doping show a reproducible switching in the leakage current with a memory effect. Positive or negative voltage pulses…
Atomic force microscopy-based mechanobiology
The potential of combining AFM with complementary techniques, including optical microscopy and spectroscopy of mechanosensitive fluorescent constructs, super-resolution microscopy, the patch clamp technique and the use of microstructured and fluidic devices to characterize the 3D distribution of mechanical responses within biological systems are outlined.
Label-free protein assay based on a nanomechanical cantilever array
Both myoglobin and creatin kinase could be detected independently using cantilevers functionalized with the corresponding antibodies, in unspecific protein background, and this approach permits the use of up to seven different antigen–antibody reactions simultaneously, including an additional thermomechanical and chemical in situ reference.
Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array
- R. McKendry, Jiayun Zhang, C. Gerber
- Biology, EngineeringProceedings of the National Academy of Sciences…
- 15 July 2002
It is shown that cantilever arrays can be used to investigate the thermodynamics of biomolecular interactions mechanically, and it is found that the specificity of the reaction on a cantilevers is consistent with solution data.