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MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
It is suggested that microRNA profiling of circulating tumor exosomes could potentially be used as surrogate diagnostic markers for biopsy profiling, extending its utility to screening asymptomatic populations. Expand
Exosomal microRNA: a diagnostic marker for lung cancer.
The significant difference in total exosome and miRNA levels between lung cancer patients and controls, and the similarity between the circulating exosomal miRNAs and the tumor-derived miRNA patterns, suggest that circulating exOSomal miRNA might be useful as a screening test for lung adenocarcinoma. Expand
Exosome isolation for proteomic analyses and RNA profiling.
While the existence of exosomes has been known for over three decades, they have garnered recent interest due to their potential diagnostic and therapeutic relevance. The expression and release ofExpand
Specific Isolation of Placenta‐Derived Exosomes from the Circulation of Pregnant Women and Their Immunoregulatory Consequences 1
In normal pregnancy, as factors linked with early immunomodulation decline, placental exosomes become critical in modulating T‐cell activation, suppressing effector T cells by enhancing lymphocyte apoptosis and CD3‐zeta loss. Expand
Pregnancy-Associated Exosomes and Their Modulation of T Cell Signaling1
It is demonstrated that exosomes from pregnancies ultimately delivering at term are present at significantly greater concentrations than those from pregnancies delivering preterm; however, exosome from term-delivering pregnancies also exhibit significantly greater suppression of CD3-ζ and JAK3. Expand
Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments
Tumor exosomes of tumor origin can be found within neoplastic lesions and in biologic fluids from cancer patients, implying a potential role of these pathways in in vivo tumor progression and systemic paraneoplastic syndromes. Expand
The origin, function, and diagnostic potential of RNA within extracellular vesicles present in human biological fluids
Tumor-derived extracellular vesicles express components responsible for angiogenesis promotion, stromal remodeling, signal pathway activation through growth factor/receptor transfer, chemoresistance, and genetic exchange and their presence in the peripheral circulation may serve as a surrogate for tumor biopsies, enabling real-time diagnosis and disease monitoring. Expand
Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects
Results indicate that, while ‘exosomes’ express tumour antigens, leading to their proposed utility as tumour vaccines, they also can suppress T-cell signalling molecules and induce apoptosis. Expand
Nanoparticle analysis of circulating cell-derived vesicles in ovarian cancer patients.
It is demonstrated that NTA can measure the size distributions of cell-derived vesicles comparable to other analysis instrumentation, and the use of fluorescent-labeled antibodies against specific markers with NTA allows the determination of the "phenotype" of the cell- derived vesicle concentration. Expand
Trophoblast‐Derived Exosomes Mediate Monocyte Recruitment and Differentiation
Citation Atay S, Gercel‐Taylor C, Suttles J, Mor G, Taylor DD. Trophoblast‐derived exosomes mediate monocyte recruitment and differentiation. Am J Reprod Immunol 2011; 65: 65–77