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Brain Expression Genome-Wide Association Study (eGWAS) Identifies Human Disease-Associated Variants
Genetic variants that modify brain gene expression may also influence risk for human diseases. We measured expression levels of 24,526 transcripts in brain samples from the cerebellum and temporalExpand
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Novel late-onset Alzheimer disease loci variants associate with brain gene expression
Objective: Recent genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) identified 9 novel risk loci. Discovery of functional variants within genes at these loci is requiredExpand
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Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
BackgroundGlutathione S-transferase omega-1 and 2 genes (GSTO1, GSTO2), residing within an Alzheimer and Parkinson disease (AD and PD) linkage region, have diverse functions including mitigation ofExpand
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A TMEFF2-regulated cell cycle derived gene signature is prognostic of recurrence risk in prostate cancer
BackgroundThe clinical behavior of prostate cancer (PCa) is variable, and while the majority of cases remain indolent, 10% of patients progress to deadly forms of the disease. Current clinicalExpand
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ARID3a gene profiles are strongly associated with human interferon alpha production.
Type I interferons (IFN) causes inflammatory responses to pathogens, and can be elevated in autoimmune diseases such as systemic lupus erythematosus (SLE). We previously reported unexpectedExpand
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Sexually divergent DNA methylation programs with hippocampal aging
DNA methylation is a central regulator of genome function and altered methylation patterns are indicative of biological aging and mortality. Age-related cellular, biochemical, and molecular changesExpand
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The hidden impact of inter-individual genomic variations on cellular function
An analysis of the degree of genomic variation between two individual genomes suggests that there may be considerable biochemical differences among individuals. Examination of DNA sequence variationsExpand
ORAL SESSIONS: O3-11 GENETICS: GENE EXPRESSION AND RISK FOR ALZHEIMER’S DISEASE O3-11-01 TITLE NOTAVAILABLE O3-11-02 EQTL REGULATION BY NATS IN ALZHEIMER’S DISEASE
Background:We have found thatw10% of the human brain transcriptome is under genetic control. While these expression quantitative trait loci (eQTLs) exist both in control samples and AD samples, forExpand