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The role of fatty acids in the development and progression of nonalcoholic fatty liver disease.
Nonalcoholic fatty liver disease (NAFLD) has emerged as a serious obesity-related disorder. NAFLD encompasses a wide spectrum of hepatic derangements ranging from a surfeit of fat in the liver… Expand
Greater rate of decline in maximal aerobic capacity with age in endurance-trained than in sedentary men.
- Annemarie E Pimentel, C. Gentile, H. Tanaka, D. Seals, P. Gates
- Medicine, Chemistry
- Journal of applied physiology
- 1 June 2003
To determine the relation between habitual endurance exercise status and the age-associated decline in maximal aerobic capacity [i.e., maximal O(2) consumption (Vo(2 max))] in men, we performed a… Expand
Fatness Is a Better Predictor of Cardiovascular Disease Risk Factor Profile Than Aerobic Fitness in Healthy Men
Background—The prevalence of cardiovascular disease (CVD) is partly attributable to an inactive and/or overweight population. However, the independent association of body fatness and aerobic fitness… Expand
Habitual physical activity differentially affects acute and short-term energy intake regulation in young and older adults
- E. L. V. Walleghen, J. S. Orr, C. Gentile, K. Davy, B. Davy
- International Journal of Obesity
- 6 March 2007
Background:Energy intake (EI) regulation is impaired in older adults, but it is not known if habitual physical activity affects accuracy of EI regulation in older compared with young… Expand
Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease.
The underlying causes of nonalcoholic fatty liver disease (NAFLD) are unclear, although recent evidence has implicated the endoplasmic reticulum (ER) in both the development of steatosis and… Expand
Comparison of creatine ingestion and resistance training on energy expenditure and limb blood flow.
- P. Arciero, N. Hannibal, B. Nindl, C. Gentile, J. Hamed, M. Vukovich
- Medicine, Biology
- Metabolism: clinical and experimental
- 1 December 2001
This study determined the effects of 28 days of oral creatine ingestion (days 1 to 5 = 20g/d; [5 g 4 times daily]: days 6 to 28 = 10 g/d; [5 g twice daily]) alone and with resistance training (5… Expand
Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death.
- K. T. Pfaffenbach, C. Gentile, A. Nivala, D. Wang, Y. Wei, M. Pagliassotti
- Biology, Chemistry
- American journal of physiology. Endocrinology and…
- 16 February 2010
Prolonged endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) have been linked to apoptosis via several mechanisms, including increased expression of C/EBP… Expand
The gut microbiota at the intersection of diet and human health
Diet affects multiple facets of human health and is inextricably linked to chronic metabolic conditions such as obesity, type 2 diabetes, and cardiovascular disease. Dietary nutrients are essential… Expand
Effects of 8 weeks of creatine supplementation on exercise performance and fat-free weight in football players during training
While the role of creatine in preventing muscle (peripheral) fatigue for high performance athletes is well understood, its biochemical role in prevention of mental (central) fatigue is not. Creatine… Expand
Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease.
Nonalcoholic fatty liver disease (NAFLD) represents a burgeoning public health concern in westernized nations. The obesity-related disorder is associated with an increased risk of cardiovascular… Expand