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Computational analysis of bacterial RNA-Seq data
Recent advances in high-throughput RNA sequencing (RNA-seq) have enabled tremendous leaps forward in our understanding of bacterial transcriptomes. However, computational methods for analysis ofExpand
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Virulence factors of Porphyromonas gingivalis.
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Stimulation of Toll-Like Receptor 2 in Human Platelets Induces a Thromboinflammatory Response Through Activation of Phosphoinositide 3-Kinase
Cells of the innate immune system use Toll-like receptors (TLRs) to initiate the proinflammatory response to microbial infection. Recent studies have shown acute infections are associated with aExpand
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Emerging strategies in microbial haem capture
Gram‐negative pathogenic bacteria have evolved novel strategies to obtain iron from host haem‐sequestering proteins. These include the production of specific outer membrane receptors that bindExpand
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Pathogenic strategies of the oral anaerobe, Porphyromonas gingivalis.
Adult periodontitis is a chronic inflammatory disease that affects over 49 million people in the USA alone. Porphyromonas (formerly Bacteroides) gingivalis, a Gram-negative anaerobe, has a diverseExpand
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Iron and heme utilization in Porphyromonas gingivalis.
Porphyromonas gingivalis is a Gram-negative anaerobic bacterium associated with the initiation and progression of adult periodontal disease. Iron is utilized by this pathogen in the form of heme andExpand
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Hemin-Dependent Modulation of the Lipid A Structure of Porphyromonas gingivalis Lipopolysaccharide
ABSTRACT Porphyromonas gingivalis is a periopathogen strongly associated with the development of adult-type periodontitis. Both the virulence characteristics of periopathogens and host-relatedExpand
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Characterization and expression of HmuR, a TonB-dependent hemoglobin receptor of Porphyromonas gingivalis.
The gram-negative pathogen Porphyromonas gingivalis requires hemin for growth. Hemoglobin bound to haptoglobin and hemin complexed to hemopexin can be used as heme sources, indicating that P.Expand
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A role for fimbriae in Porphyromonas gingivalis invasion of oral epithelial cells.
Isogenic mutants of Porphyromonas gingivalis which differ in the expression of fimbriae were used to examine the contribution of fimbriae in invasion of a human oral epithelial cell line (KB). At aExpand
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Innate Immune Signaling and Porphyromonas gingivalis-accelerated Atherosclerosis
Periodontal diseases are a group of diseases that lead to erosion of the hard and soft tissues of the periodontium, which, in severe cases, can result in tooth loss. Anecdotal clinical observationsExpand
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