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Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome
TLDR
Representing an efficient Nrf2 inhibitor capable of blocking NRF2-dependent proteasome activity and thereby apoptosis protection in pancreatic cancer cells, trig might be beneficial in improving anticancer therapy.
Derivation of oocyte-like cells from a clonal pancreatic stem cell line.
TLDR
A first pilot study investigating the putative germ line potential of adult PSCs is presented, and expression of various germ cell markers, such as Vasa, growth differentiation marker 9 and SSEA-1, increased in the clonal cell line, and OLCs showed additionally expression of meiosis-specific markers SCP3 and DMC1.
Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancer.
TLDR
It is shown that coculture with PMFs led to a transforming growth factor-beta1 (TGF- beta1)-dependent up-regulation of L1CAM expression, which contributed to malignant transformation of pancreatic duct cells early in PDAC tumorigenesis.
Cytoprotection “gone astray”: Nrf2 and its role in cancer
TLDR
The present review mainly addresses the conditions that promote the oncogenic function of Nrf2 and the resulting consequences providing the rationale for using NRF2 as a target structure in cancer therapy.
Identification and characterization of two functional variants in the human longevity gene FOXO3
TLDR
The authors fine-map the FOXO3-longevity association to two intronic SNPs and, using luciferase assays and EMSAs, show that these SNPs affect binding of transcription factors CTCF and SRF and associate with FoxO3 expression.
L1CAM expression in endometrial carcinomas is regulated by usage of two different promoter regions
TLDR
The results provide evidence that the L1CAM gene has two functionally active promoter sites that are used in a cell-type specific manner and provide the basis for a better understanding of L 1CAM regulation in non-neuronal/tumor cells.
Modulation of Nuclear Factor E2-related Factor-2 (Nrf2) Activation by the Stress Response Gene Immediate Early Response-3 (IER3) in Colonic Epithelial Cells
TLDR
The interference of Ier3 with the PI3K/Akt-Fyn pathway represents a novel mechanism of Nrf2 regulation that may get lost in tumors and by which IER3 exerts its stress-adaptive and tumor-suppressive activity.
Binding of the transcription factor Slug to the L1CAM promoter is essential for transforming growth factor-β1 (TGF-β)-induced L1CAM expression in human pancreatic ductal adenocarcinoma cells.
TLDR
The direct transcriptional control of L1CAM expression through Slug during TGF-β1-induced EMT of PDAC cells is demonstrated, pointing to a novel mechanism by which Slug contributes quite early to tumorigenesis.
alpha5-integrin is crucial for L1CAM-mediated chemoresistance in pancreatic adenocarcinoma.
TLDR
Blockade or knock-down of alpha5-integrin in the L1CAM expressing PDAC cell lines PT45-P1res, Colo357 and Panc1 increased anti-cancer drug sensitivity and mutational loss of the integrin binding site in the H2O molecule or the blockade ofalpha5-Integrin abolished the induction of iNOS expression and chemoresistance by L1 cAM.
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