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Definitive high resolution typing of HLA-E allelic polymorphisms: Identifying potential errors in existing allele data.
A set of robust PCR-SSP reactions were developed for each of the five polymorphic sites that define the five alleles of the HLA class Ib gene, HLA-E. This method was developed using 28 homozygous… Expand
Fine mapping of T-cell immunoglobulin mucin domain gene 1 failed to detect a significant association with multiple sclerosis.
The T-cell immunoglobulin mucin (TIM) gene family encodes receptors on T-cells that regulate Th1- and Th2-cell-mediated immunity. Recently published data implied differential expression of human TIM… Expand
Mutations in the gene for toll-like receptor 4 and multiple sclerosis.
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system with heterogeneous pathological features, disease courses and genetical backgrounds. In this study we… Expand
Modulation of tumor necrosis factor-alpha-mediated cytotoxicity by changes of the cellular methylation state: mechanism and in vivo relevance.
A combination of adenosine (Ado) and homocysteine (Homo) enhances tumor necrosis factor (TNF)-alpha cytotoxicity in vitro and in vivo in several tumor cells. Ado and Homo at concentrations that… Expand
Fyx is associated with two missense point mutations in its gene and can be detected by PCR-SSP.
The Duffy blood group antigens are encoded by the Duffy gene with its three major alleles: Fy*A (Fya+), Fy*B (Fyb+), and a nonexpressed Fy*Fy (Fya-b-), which is most commonly found among black… Expand
Genetic variants in the tumor necrosis factor receptor II gene in patients with multiple sclerosis.
Common genetic variants have been shown to influence disease susceptibility, disease course, or both in multiple sclerosis (MS). Several studies have suggested a role for tumor necrosis factor-alpha… Expand
13th IHWS NK/KIR Joint Report. Killer immunoglobulin-like receptor genotypes, haplotypes and haplotype segregation patterns evaluated in the workshop KIR reference DNA panel.
Expression of low-frequency Ala108Pro substitution in the platelet glycoprotein Ibbeta gene.
- S. Kunishima, C. Gassner, C. Inoue, T. Kamiya, K. Ozawa
- Biology, Medicine
- European journal of immunogenetics : official…
- 1 April 2003
We determined the gene frequency of the glycoprotein (GP) Ibbeta Ala108Pro substitution. The Pro108 allele was not found in 208 healthy Japanese and 200 healthy Caucasians. In vitro expression… Expand
Mapping HLA for single nucleotide polymorphisms.
Knowledge of DNA sequence variation may help us understand how genetic variability gives rise to functional variability and, in so doing, revolutionize the development of strategies to combat and… Expand