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Measures of frailty in population-based studies: an overview
BackgroundAlthough research productivity in the field of frailty has risen exponentially in recent years, there remains a lack of consensus regarding the measurement of this syndrome. This overviewExpand
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Grip Strength across the Life Course: Normative Data from Twelve British Studies
Introduction Epidemiological studies have shown that weaker grip strength in later life is associated with disability, morbidity, and mortality. Grip strength is a key component of the sarcopenia andExpand
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Influence of individual and combined health behaviors on total and cause-specific mortality in men and women: the United Kingdom health and lifestyle survey.
BACKGROUND Physical activity, diet, smoking, and alcohol consumption have been shown to be related to mortality. We examined prospectively the individual and combined influence of these risk factorsExpand
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GWAS on family history of Alzheimer’s disease
Alzheimer’s disease (AD) is a public health priority for the 21st century. Risk reduction currently revolves around lifestyle changes with much research trying to elucidate the biologicalExpand
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Migrant studies in multiple sclerosis
To re-evaluate how migrant studies contribute to our understanding of the epidemiology and aetiology of multiple sclerosis, we undertook a systematic review of all relevant studies published inExpand
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Sex Differences in the Adult Human Brain: Evidence from 5216 UK Biobank Participants
Abstract Sex differences in the human brain are of interest for many reasons: for example, there are sex differences in the observed prevalence of psychiatric disorders and in some psychologicalExpand
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Ageing and brain white matter structure in 3,513 UK Biobank participants
Quantifying the microstructural properties of the human brain's connections is necessary for understanding normal ageing and disease. Here we examine brain white matter magnetic resonance imagingExpand
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Lutein and zeaxanthin status and risk of age-related macular degeneration.
PURPOSE To investigate the relation between plasma concentrations of lutein and zeaxanthin and age-related macular degeneration in a group of elderly men and women. METHODS The WisconsinExpand
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Bright Children Become Enlightened Adults
We examined the prospective association between general intelligence (g) at age 10 and liberal and antitraditional social attitudes at age 30 in a large (N = 7,070), representative sample of theExpand
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Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity
OBJECTIVE Fixed genomic variation explains only a small proportion of the risk of adiposity. In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes inExpand
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