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Polyriboinosinic polyribocytidylic acid [poly(I:C)]/TLR3 signaling allows class I processing of exogenous protein and induction of HIV-specific CD8+ cytotoxic T lymphocytes.
In the case of viral infection, various viral proteins and genetic components are disseminated in the body. The former viral proteins may be captured by immature dendritic cells (DC) and the latterExpand
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  • Open Access
Negative effects of chronic inflammatory periodontal disease on diabetes mellitus.
Periodontal disease is the result of a complex interplay of bacterial infection and host responses, and is often modified by various systemic diseases such as diabetes mellitus. Such diseases areExpand
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Short-Time Exposure of Hyperosmolarity Triggers Interleukin-6 Expression in Corneal Epithelial Cells
Purpose: Although tear hyperosmolarity is assumed to play a major role in dry eye disease, correlation between the level of hyperosmolarity and inflammation remains unclear. The purpose of this studyExpand
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Tyrosine triple mutated AAV2-BDNF gene therapy in a rat model of transient IOP elevation
Purpose We examined the neuroprotective effects of exogenous brain-derived neurotrophic factor (BDNF), which provides protection to retinal ganglion cells (RGCs) in rodents, in a model of transientExpand
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  • Open Access
Efficacy of Rebamipide Instillation for Contact Lens Discomfort With Dry Eye
Objective: To examine the effects of rebamipide ophthalmic solution on the symptoms, signs, and cytokine concentrations in tear fluid among soft contact lens (SCL) wearers with Dry eye disease (DED).Expand
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Improvements in Signs and Symptoms of Dry Eye after Instillation of 2% Rebamipide.
PURPOSE Because dry eye greatly reduces quality of life, this study aimed to examine rebamipide instillation in patients with dry eye and assess the improvement of signs and symptoms as evaluatedExpand
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Mometasone furoate nasal spray relieves the ocular symptoms of seasonal allergic rhinoconjunctivitis.
BACKGROUND Recent studies have examined the effects of intranasal corticosteroids (INSs) in relieving the ocular symptoms of seasonal allergic rhinoconjunctivitis (SAR) and perennial allergicExpand
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The level of thymic expression of RPE65 inversely correlates with its capacity to induce experimental autoimmune uveitis (EAU) in different rodent strains.
We have previously shown that immunization with RPE65 produces in rats of four strains a severe inflammatory eye disease, designated experimental autoimmune uveitis (EAU). Here, we examined theExpand
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Adeno-associated virus type 8 vector–mediated expression of siRNA targeting vascular endothelial growth factor efficiently inhibits neovascularization in a murine choroidal neovascularization model
Purpose To assess the feasibility of a gene therapeutic approach to treating choroidal neovascularization (CNV), we generated an adeno-associated virus type 8 vector (AAV2/8) encoding an siRNAExpand
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The correlation between plasma osmolarity and tear osmolarity
PurposeTo the correlation between plasma osmolarity (Posm) and tear osmolarity (Tosm) in patients (54 patients, 88 eyes) who underwent cataract surgery was evaluated.MethodsBefore cataract surgery,Expand
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