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Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts.
- X. Warot, C. Fromental-Ramain, V. Fraulob, P. Chambon, P. Dollé
- Medicine, BiologyDevelopment
- 1 December 1997
Hoxa-13 and Hoxd-13 play important roles in the morphogenesis of the terminal part of the gut and urogenital tract during embryogenesis and postnatal development, demonstrating that both genes act, in a partly redundant manner, during early Morphogenesis of posterior trunk structures.
Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod.
- C. Fromental-Ramain, X. Warot, N. Messadecq, M. Lemeur, P. Dollé, P. Chambon
- 1 October 1996
It is reported here that targeted disruption of the Hoxa-13 gene leads to a specific forelimb and hindlimb autopodal phenotype, distinct from that of theHoxd-13 paralogous gene inactivation, indicating that these genes act in a partially redundant manner.
Regulation of number and size of digits by posterior Hox genes: a dose-dependent mechanism with potential evolutionary implications.
- J. Zákány, C. Fromental-Ramain, X. Warot, D. Duboule
- BiologyProceedings of the National Academy of Sciences…
- 9 December 1997
It is reported here that the group 11, 12, and 13 genes control both the size and number of murine digits in a dose-dependent fashion, rather than through a Hox code involving differential qualitative functions, which suggests that digits and external genitalia share this genetic control mechanism.
Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning.
The present and previously reported results show that disruption of different Hox genes can produce similar vertebral transformations, thus supporting a combinatorial code model for specification of vertebral identity by H Cox genes.
Expression of the zebrafish gene hlx-1 in the prechordal plate and during CNS development.
Analysis of hlx-1 expression by in situ hybridization reveals several particularly interesting features which suggest a role in the determination of head mesoderm as well as in patterning of the rostral brain in zebrafish embryos.
ATP-driven chromatin remodeling activity and histone acetyltransferases act sequentially during transactivation by RAR/RXR In vitro.
Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton.
- B. Favier, F. Rijli, C. Fromental-Ramain, V. Fraulob, P. Chambon, P. Dollé
- 1 February 1996
It is found that a targeted disruption of Hoxa-10 has almost no effect in the forelimbs, while it affects the proximal hindlimb skeleton, and functional redundancy can occur even between non-paralogous Abdominal B-related Hox genes.
pannier encodes two structurally related isoforms that are differentially expressed during Drosophila development and display distinct functions during thorax patterning
Toutatis, a TIP5-related protein, positively regulates Pannier function during Drosophila neural development
The results suggest that Tou and Iswi may belong to a complex that directly regulates the activity of Pnr and Chip during enhancer-promoter communication, possibly through chromatin remodelling.
Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes.
It is concluded that paralogous Hox genes can have a unique role in patterning specific axial regions in addition to their redundant function at other AP levels.