C. Freund

Publications113
h-index32
Citations3,038
Highly Influential Citations132
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Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation
Antigen presentation by major histocompatibility complex (MHC) proteins is essential for adaptive immunity. Prior to presentation, peptides need to be generated from proteins that are either produced… Expand
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Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation.
An intracellular protein termed CD2 binding protein 2 (CD2BP2), which binds to a site containing two PPPGHR segments within the cytoplasmic region of CD2, was identified. Mutagenesis and NMR analysis… Expand
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GYF Domain Proteomics Reveals Interaction Sites in Known and Novel Target Proteins*S
GYF domains are conserved eukaryotic adaptor domains that recognize proline-rich sequences. Although the structure and function of the prototypic GYF domain from the human CD2BP2 protein have been… Expand
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Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease
Background— Pluripotent stem cells (PSCs) offer a new paradigm for modeling genetic cardiac diseases, but it is unclear whether mouse and human PSCs can truly model both gain- and loss-of-function… Expand
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The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences
T cell activation through the CD2 cell surface receptor is transmitted by proline-rich sequences within its cytoplasmic tail. A membrane-proximal proline-rich tandem repeat, involved in cytokine… Expand
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Recognition Sequences for the GYF Domain Reveal a Possible Spliceosomal Function of CD2BP2*
Protein-protein interactions are often mediated by small domains that recognize solvent-exposed peptide sequences. Deciphering the recognition code for these adapter domains is an important step in… Expand
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SH3 domain recognition of a proline‐independent tyrosine‐based RKxxYxxY motif in immune cell adaptor SKAP55
Src‐homology 3 (SH3) domains recognize PXXP core motif preceded or followed by positively charged residue(s). Whether SH3 domains recognize motifs other than proline‐based sequences is unclear. In… Expand
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Isolation and properties of a nitrile hydratase from the soil fungus Myrothecium verrucaria that is highly specific for the fertilizer cyanamide and cloning of its gene.
A protein was purified from crude extracts of the soil fungus Myrothecium verrucaria by gel filtration and hydrophobic chromatography to homogeneity; this protein catalyzed the stoichiometric… Expand
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Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules
Intracellular protein interaction domains are essential for eukaryotic signaling. In T cells, the CD2BP2 adaptor binds two membrane‐proximal proline‐rich motifs in the CD2 cytoplasmic tail via its… Expand
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Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment
Cellular FLICE-inhibitory protein (c-FLIP) proteins are known as potent inhibitors of death receptor-mediated apoptosis by interfering with caspase-8 activation at the death-inducing signaling… Expand
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