• Publications
  • Influence
Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine.
TLDR
Alemtuzumab has significant activity in poor-prognosis, fludarabine-treated CLL patients, however, because of a relatively high incidence of opportunistic infections accompanying profound lymphopenia, future protocols should include mandatory prophylaxis. Expand
Expression of transforming growth factor alpha and its messenger ribonucleic acid in human breast cancer: its regulation by estrogen and its possible functional significance.
TLDR
Broad expression of TGF alpha in human breast cancer, its hormonal regulation in an estrogen-responsive cell line, and its possible functional significance in MCF-7 cell growth are demonstrated. Expand
Plasma microRNAs as novel biomarkers for early detection of lung cancer.
TLDR
Results indicate thatmiR-155, miR-197, andMiR-182 can be potential non-invasive biomarkers for early detection of lung cancer. Expand
Brief-duration high-intensity chemotherapy for patients with small noncleaved-cell lymphoma or FAB L3 acute lymphocytic leukemia: results of cancer and leukemia group B study 9251.
TLDR
Aggressively delivered chemotherapy is potentially curative in as many as half of patients with SNC and the L3 ALL variant, and this treatment regimen had considerable neurologic toxicity and has been modified. Expand
Lipid Metabolism, Apoptosis and Cancer Therapy
TLDR
Understanding the underlying molecular mechanism of lipid metabolism and the function of different lipid molecules could provide the basis for cancer cell death rationale, discover novel and potential targets, and develop new anticancer drugs for cancer therapy. Expand
Acquisition of hormone-independent growth in MCF-7 cells is accompanied by increased expression of estrogen-regulated genes but without detectable DNA amplifications.
TLDR
Data indicate that progression to hormone independence can occur without major gene amplifications or a high constitutive induction of phosphoinositide metabolism, and indicates that DNA amplifications may be acquired during the early initiation and/or promotional events of carcinogenesis. Expand
Insight into Sweet's syndrome and associated-malignancy: a review of the current literature.
TLDR
Insight is provided into the pathophysiology, clinical presentation, diagnostic work, differential diagnosis and management of malignancy-associated Sweet's syndrome published in reported cases. Expand
Suramin interferes with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo.
TLDR
An anticachectic role for the experimental drug suramin is established, since it partially blocks the catabolic effects associated with the growth of this tumor in vivo, in part by interfering with the binding of IL-6 to its receptor. Expand
A randomized phase 2 study of PBPC mobilization by stem cell factor and filgrastim in heavily pretreated patients with Hodgkin's disease or non-Hodgkin's lymphoma
TLDR
In this study of heavily pretreated lymphoma patients, SCF plus filgrastim was more effective than fil grastim alone for mobilizing PBPC for harvesting and transplantation after high-dose chemotherapy. Expand
Lung cancer screening: from imaging to biomarker
TLDR
Screening methods for detection of lung cancer using free circulating DNA and RNA, exosomal microRNA, circulating tumor cells and various lung cancer specific antigens have been studied extensively and novel screening methods are being developed with encouraging results. Expand
...
1
2
3
4
5
...