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The complete genome sequence of the gastric pathogen Helicobacter pylori
Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification, and consistent with its restricted niche, it has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity.
Genome sequence of the human malaria parasite Plasmodium falciparum
The genome sequence of P. falciparum clone 3D7 is reported, which is the most (A + T)-rich genome sequenced to date and is being exploited in the search for new drugs and vaccines to fight malaria.
Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi
The genome of the bacterium Borrelia burgdorferi B31, the aetiologic agent of Lyme disease, contains a linear chromosome of 910,725 base pairs and at least 17 linear and circular plasmids with a combined size of more than 533,000 base pairs, which suggest their limited metabolic capacities reflect convergent evolution by gene loss from more metabolically competent progenitors.
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
The V. cholerae genomic sequence provides a starting point for understanding how a free-living, environmental organism emerged to become a significant human bacterial pathogen.
Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440.
- K. Nelson, C. Weinel, +40 authors C. Fraser
- Biology, MedicineEnvironmental microbiology
- 1 December 2002
Pseudomonas putida is a metabolically versatile saprophytic soil bacterium that has been certified as a biosafety host for the cloning of foreign genes. The bacterium also has considerable potential…
Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae
A motif identified within the signal peptide of proteins is potentially involved in targeting these proteins to the cell surface of low–guanine/cytosine Gram-positive species.
Role of Mobile DNA in the Evolution of Vancomycin-Resistant Enterococcus faecalis
The complete genome sequence of Enterococcus faecalisV583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA, which probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.
Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome".
- H. Tettelin, V. Masignani, +43 authors C. Fraser
- Biology, MedicineProceedings of the National Academy of Sciences…
- 27 September 2005
The genomic sequence of six strains representing the five major disease-causing serotypes of Streptococcus agalactiae, the main cause of neonatal infection in humans, was generated and Mathematical extrapolation of the data suggests that the gene reservoir available for inclusion in the S. agalactic pan-genome is vast and that unique genes will continue to be identified even after sequencing hundreds of genomes.
The Minimal Gene Complement of Mycoplasma genitalium
Comparison of the Mycoplasma genitalium genome to that of Haemophilus influenzae suggests that differences in genome content are reflected as profound differences in physiology and metabolic capacity between these two organisms.
Insights on Evolution of Virulence and Resistance from the Complete Genome Analysis of an Early Methicillin-Resistant Staphylococcus aureus Strain and a Biofilm-Producing Methicillin-Resistant…
Gene transfer between staphylococci and low-GC-content gram-positive bacteria appears to have shaped their virulence and resistance profiles, and overall differences in pathogenicity can be attributed to genome islands in S. aureus and S. epidermidis.