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Chronic Administration of Statins Alters Multiple Gene Expression Patterns in Mouse Cerebral Cortex
Statins have been reported to lower the risk of developing Alzheimer's disease; however, the mechanism of this potentially important neuroprotective action is not understood. Lowering cholesterolExpand
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Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment
The present study determined if chronic simvastatin administration in vivo would provide neuroprotection in brain cells isolated from guinea pigs after challenge with the Bcl-2 inhibitor HA 14-1 orExpand
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Simvastatin protects neurons from cytotoxicity by up‐regulating Bcl‐2 mRNA and protein
Statins are most commonly prescribed to reduce hypercholesterolemia; however, recent studies have shown that statins have additional benefits, including neuroprotection. Until now, the mechanismExpand
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Cholesterol: Coupling between membrane microenvironment and ABC transporter activity.
Lipid composition of biological membranes is closely related to the function of the ATP-binding cassette (ABC) transporter P-Glycoprotein (Pgp). Herein, we studied how membrane physico-chemicalExpand
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Plant derived omega-3-fatty acids protect mitochondrial function in the brain.
Perilla frutescens seed oil (PFSO) represents a rich source of unsaturated fatty acids, especially of omega-3 linolenic acid and is commonly used as herbal food supplement with beneficial effects onExpand
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Collocation Methods for the Investigation of Periodic Motions of Constrained Multibody Systems
The investigation of periodic motions of constrained multibodysystems requires the numerical solution of differential-algebraicboundary value problems. After briefly surveying the basics ofExpand
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Heterologously Expressed GLT-1 Associates in ∼200-nm Protein-Lipid Islands
The glutamate transporter GLT-1 from Rattus norvegicus was expressed at high level in baby hamster kidney (BHK-21) cells by the Semliki Forest Virus expression system. We examined the expressed GLT-1Expand
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Heterologously expressed GLT-1 associates in approximately 200-nm protein-lipid islands.
The glutamate transporter GLT-1 from Rattus norvegicus was expressed at high level in baby hamster kidney (BHK-21) cells by the Semliki Forest Virus expression system. We examined the expressed GLT-1Expand
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