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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
The beneficial effects of inflammation devoted to the neutralization of dangerous/harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution, according to the antagonistic pleiotropy theory of aging. Expand
Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases.
The session on inflammation of the Advances in Gerosciences meeting held at the National Institutes of Health/National Institute on Aging in Bethesda on October 30 and 31, 2013 was aimed at defining these important unanswered questions about inflammaging. Expand
Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians
Evidence is provided for the fact that the ageing process deeply affects the structure of the human gut microbiota, as well as its homeostasis with the host's immune system, because of its crucial role in the host physiology and health status. Expand
A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolcarbocyanine
A new method for the cytofluorimetric analysis of mitochondrial membrane potential in intact cells has been developed by using the lipophilic cationic probeExpand
Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans
It is proposed that inflammaging can be flanked by anti-inflammaging as major determinants not only of immunosenescence but eventually of global aging and longevity. Expand
JC‐1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis
Data indicate that JC‐1 is a reliable probe for analyzing ΔΨ changes with flow cytometry, while the others show a lower sensitivity (R123), or a non‐coherent behaviour, due to a high sensitivity to changes in plasmamembrane potential [DiOC6(3]. Expand
Geroscience: Linking Aging to Chronic Disease
Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches, and it is critical to expand geroscience research directed at extending human healthspan. Expand
Gut Microbiota and Extreme Longevity
This work provides for the first time the phylogenetic microbiota analysis of semi-supercentenarians, i.e., 105-109 years old, in comparison to adults, elderly, and centenarian, thus reconstructing the longest available human microbiota trajectory along aging. Expand
Increased cytokine production in mononuclear cells of healthy elderly people
The increased production of pro‐inflammatory cytokines by stimulated mononuclear cells of healthy aged subjects may be relevant to several aspects of age‐associated pathological events, including atherosclerosis, osteoporosis, fibrosis and dementia. Expand
Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans.
This study focuses on how the insulin/IGF-I pathway controls yeast, nematode, fruit fly, and rodent life spans and how it is related to the aging process in humans to outline the prospect of a unifying mechanism in the genetics of longevity. Expand