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The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation.
- M. Sheets, C. Fox, T. Hunt, G. V. Vande Woude, M. Wickens
- Biology, Medicine
- Genes & development
- 15 April 1994
The results suggest that the 3' UTRs of cyclin and c-mos mRNAs control not only whether or not an mRNA is turned on during maturation, but when that activation occurs and to what extent. Expand
Mechanisms controlling differential promoter-occupancy by the yeast forkhead proteins Fkh1p and Fkh2p: implications for regulating the cell cycle and differentiation.
Interestingly, the in vitro DNA-binding assays revealed that bona fide Fkh target promoters contained two or more Fkh-binding sites that allowed the Fkh1p and Fkh2p proteins to form multiple protein-DNA complexes in vitro. Expand
Forkhead genes in transcriptional silencing, cell morphology and the cell cycle. Overlapping and distinct functions for FKH1 and FKH2 in Saccharomyces cerevisiae.
Interestingly, deletions in either FKH1 or FKh2 alone caused subtle but opposite effects on cell-cycle progression and CLB2 mRNA expression, consistent with a role for each of these genes in modulating the cell cycle and having opposing effects on silencing. Expand
Poly(A) addition during maturation of frog oocytes: distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU.
It is hypothesized that polyadenylation may be responsible for the translational activation of a family of mRNAs essential for maturation, and injected short, synthetic RNA substrates into Xenopus oocytes to analyze this reaction and lead to speculation. Expand
Nuclear polyadenylation factors recognize cytoplasmic polyadenylation elements.
It is suggested that sequences upstream of AAUAAA that are required for cleavage and polyadenylation of certain pre-mRNAs in the nucleus may be functionally equivalent to the upstream, U-rich sequences that function in the cytoplasm, enhancing CPSF binding. Expand
The Origin Recognition Complex and Sir4 Protein Recruit Sir1p to Yeast Silent Chromatin through Independent Interactions Requiring a Common Sir1p Domain
- M. E. Bose, Kristopher H. McConnell, +4 authors C. Fox
- Biology, Medicine
- Molecular and Cellular Biology
- 15 January 2004
It is shown that a discrete domain within Sir1p, the ORC interaction region (OIR), was necessary and sufficient for aSir1p-ORC interaction, and this data support a model in which Sir1 p's association with HMR a is mediated by separable Sir2p-OrC and Sir1n-Sir4p interactions requiring a common Sir1P domain. Expand
Differential DNA affinity specifies roles for the origin recognition complex in budding yeast heterochromatin.
The origin recognition complex's two roles at the heterochromatic HMRa locus in Saccharomyces cerevisiae were regulated by differences in the ORC's interaction with its target site, which could modulate ORC activity within aheterochromatin domain in vivo. Expand
A region of the Sir1 protein dedicated to recognition of a silencer and required for interaction with the Orc1 protein in saccharomyces cerevisiae.
Eight recessive alleles of SIR1 were discovered that encode mutant Sir1 proteins specifically defective in their ability to recognize the HMR-E silencer, and the approach used to find these mutations may be applicable to defining interaction surfaces on proteins involved in other processes that require the assembly of macromolecular complexes. Expand
Structural basis of the Sir1-origin recognition complex interaction in transcriptional silencing.
- Zhonggang Hou, D. Bernstein, C. Fox, J. Keck
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 14 June 2005
High-resolution crystal structures of the ORC interaction region (OIR) of Sir1p and that of the complex formed between the OIR and BAH domains are presented and provide important structural insights into a protein-protein interaction critical for the formation of a specialized chromatin domain within eukaryotic chromosomes. Expand
The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin.
Genome-wide analyses of ORC binding in ORC1 and orc1bahDelta cells revealed that the Orc1BAH domain contributed to ORC's association with most yeast origins, including a class of origins highly dependent on the Orc 1BAHdomain for ORC association (orc1bah Delta-sensitive origins). Expand