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Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study.
BACKGROUND Optimum management of clinically localised prostate cancer presents unique challenges because of the highly variable and often indolent natural history of the disease. To predict diseaseExpand
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The Evolutionary History of Lethal Metastatic Prostate Cancer
Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple competing subclones within a single primary tumour. This evolutionary process culminates in the formation ofExpand
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Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis
A human antibody to interleukin-17A is well tolerated and may be effective in the treatment of psoriasis, rheumatoid arthritis, and noninfectious uveitis. Stopping Inflammation in Its TracksExpand
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Referral patterns of uveitis in a tertiary eye care center.
OBJECTIVE To analyze the referral patterns and diagnosis of uveitis during the past decade in a large tertiary eye center. DESIGN The records of 1237 patients with uveitis referred to theExpand
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Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins andExpand
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Serious complications of topical mitomycin-C after pterygium surgery.
BACKGROUND The use of topical mitomycin (mitomycin-C) as a medical adjunct to pterygium and glaucoma surgery is increasing. METHODS The authors report on a series of 10 patients who experiencedExpand
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Stevens-Johnson syndrome and toxic epidermal necrolysis: a review of the literature.
OBJECTIVE To perform a comprehensive review of Stevens-Johnson syndrome and toxic epidermal necrolysis. DATA SOURCES A MEDLINE search was performed for the years 1975 to 2003 using the keywordsExpand
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Resistance to herpes stromal keratitis conferred by an lgG2a-derived peptide
NOT all peripheral tissue antigens enter the thymus and it is unclear how the immune system remains tolerant to this class of self antigen. As tolerance to self peptides can generate gaps in theExpand
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Clinical characteristics of a large cohort of patients with scleritis and episcleritis.
OBJECTIVE To evaluate the demographic characteristics, clinical features, ocular complications, and disease associations of patients with scleritis and episcleritis; as well as to delineate the riskExpand
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Changing patterns in uveitis of childhood.
BACKGROUND Although uveitis is relatively uncommon in children, its diagnosis and management present a distinct clinical challenge for the physician. An improved knowledge of disease patterns andExpand
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